PMID- 21623602
OWN - NLM
STAT- MEDLINE
DCOM- 20111024
LR  - 20211020
IS  - 1976-2437 (Electronic)
IS  - 0513-5796 (Print)
IS  - 0513-5796 (Linking)
VI  - 52
IP  - 4
DP  - 2011 Jul
TI  - Impact of acute kidney injury on clinical outcomes after ST elevation acute 
      myocardial infarction.
PG  - 603-9
LID - 10.3349/ymj.2011.52.4.603 [doi]
AB  - PURPOSE: This study aimed to compare the incidence and clinical significance of 
      transient versus persistent acute kidney injury (AKI) on acute ST elevation 
      myocardial infarction (STEMI). MATERIALS AND METHODS: The study was a 
      retrospective cohort of 855 patients with STEMI. AKI was defined as an increase 
      of >/=0.3 mg/dL in creatinine level at any point during hospital stay. The study 
      population was classified into 5 groups: 1) patients without AKI; 2) patients 
      with mild AKI that was resolved by discharge (creatinine change less than 
      0.5mg/dL compared with admission creatinine during hospital stay, transient mild 
      AKI); 3) patients with mild AKI that did not resolve by discharge (persistent 
      mild AKI); 4) patients with moderate/severe AKI that was resolved by discharge 
      (creatinine change more than 0.5 mg/dL compared with admission creatinine, 
      transient moderate/severe AKI); 5) patients with moderate/ severe AKI that did 
      not resolve by discharge (persistent moderate/severe AKI). We investigated 1-year 
      all-cause mortality after hospital discharge for the primary outcome of the 
      study. The relation between AKI and 1-year mortality after STEMI was analyzed. 
      RESULTS: AKI occurred in 74 (8.7%) patients during hospital stay. Adjusted hazard 
      ratio for mortality was 3.139 (95% CI 0.764 to 12.897, p=0.113) in patients with 
      transient, mild AKI, and 8.885 (95% CI 2.710 to 29.128, p<0.001) in patients with 
      transient, moderate/severe AKI compared to patients without AKI. Persistent 
      moderate/severe AKI was also independent predictor of 1 year mortality (hazard 
      ratio, 5.885; 95% CI 1.079 to 32.101, p=0.041). CONCLUSION: Transient and 
      persistent moderate/severe AKI during acute myocardial infarction is strongly 
      related to 1-year all cause mortality after STEMI.
FAU - Kim, Min Jee
AU  - Kim MJ
AD  - Department of Internal Medicine, Chonnam National University Medical School, 8 
      Hak-dong, Dong-gu, Gwangju 501-757, Korea.
FAU - Choi, Hong Sang
AU  - Choi HS
FAU - Oh, Seul Hyun
AU  - Oh SH
FAU - Lee, Hyung Chul
AU  - Lee HC
FAU - Kim, Chang Seong
AU  - Kim CS
FAU - Choi, Joon Seok
AU  - Choi JS
FAU - Park, Jeong Woo
AU  - Park JW
FAU - Bae, Eun Hui
AU  - Bae EH
FAU - Ma, Seong Kwon
AU  - Ma SK
FAU - Kim, Nam Ho
AU  - Kim NH
FAU - Jeong, Myung Ho
AU  - Jeong MH
FAU - Kim, Soo Wan
AU  - Kim SW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Acute Kidney Injury/complications/diagnosis/*epidemiology
MH  - Aged
MH  - Creatinine/blood
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*complications/diagnosis/mortality
MH  - Prognosis
MH  - Retrospective Studies
PMC - PMC3104458
COIS- The authors have no financial conflicts of interest.
EDAT- 2011/05/31 06:00
MHDA- 2011/10/25 06:00
PMCR- 2011/07/01
CRDT- 2011/05/31 06:00
PHST- 2011/05/31 06:00 [entrez]
PHST- 2011/05/31 06:00 [pubmed]
PHST- 2011/10/25 06:00 [medline]
PHST- 2011/07/01 00:00 [pmc-release]
AID - 201107603 [pii]
AID - 10.3349/ymj.2011.52.4.603 [doi]
PST - ppublish
SO  - Yonsei Med J. 2011 Jul;52(4):603-9. doi: 10.3349/ymj.2011.52.4.603.