PMID- 21623833
OWN - NLM
STAT- MEDLINE
DCOM- 20120119
LR  - 20211020
IS  - 1365-2605 (Electronic)
IS  - 0105-6263 (Print)
IS  - 0105-6263 (Linking)
VI  - 34
IP  - 4 Pt 2
DP  - 2011 Aug
TI  - Impact of classification of mixed germ-cell tumours on incidence trends of 
      non-seminoma.
PG  - e274-7
LID - 10.1111/j.1365-2605.2011.01187.x [doi]
AB  - Seminomas and non-seminomas [embryonal carcinomas, yolk sac tumours, teratomas, 
      choriocarcinomas, mixed germ-cell tumours (MGCT)] are the major histological 
      types of testicular germ-cell tumours (TGCT). TGCTs composed of both seminomatous 
      and non-seminomatous elements have been coded as their non-seminoma component in 
      the World Health Organization classification. In the late 1980s, a provisional 
      International Classification of Diseases for Oncology (ICD-O) morphology code for 
      MGCT was introduced. Using data from the Surveillance, Epidemiology and End 
      Results Program and two population-based German cancer registries, we examined 
      the impact of MGCT classification on TGCT trends. Cases were identified using 
      ICD-O topography (ICD-9: 186; ICD-10: C62) and morphology codes 
      (seminoma=9060-9062, 9064; embryonal carcinoma=9070; yolk sack tumour=9071; 
      teratoma=9080-9084, 9102; choriocarcinoma=9100, 9101; MGCT=9085; all 
      non-seminoma=9065-9102). As MGCTs and teratoma are often grouped as a single 
      histological group, we analysed teratoma both including and excluding MGCTs. 
      Between 1988 and 2007, incidence rates of MGCT in the US increased 407%. Rates of 
      teratoma including MGCT increased 80%, whereas rates of teratoma excluding MGCT 
      decreased 71%. Rates of embryonal carcinoma [-40%] and choriocarcinoma [-22%] 
      also declined, suggesting that the code for MGCT is now being used for any mixed 
      histology. Similar declines in incidence were observed in the German comparison 
      populations. The declines in incidence of teratoma (excluding MGCT), embryonal 
      carcinoma and choriocarcinoma in the US data since 1988 are likely in part 
      because of increases in classifying any TGCT with mixed histology as MGCT. These 
      results suggest that analysis of trends in specific histological types of 
      non-seminoma should be interpreted cautiously.
CI  - (c) 2011 The Authors. International Journal of Andrology (c) 2011 European Academy of 
      Andrology.
FAU - Trabert, B
AU  - Trabert B
AD  - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology 
      and Genetics, National Cancer Institute, National Institutes of Health, 
      Rockville, MD 20852-7234, USA. trabertbl@mail.nih.gov
FAU - Stang, A
AU  - Stang A
FAU - Cook, M B
AU  - Cook MB
FAU - Rusner, C
AU  - Rusner C
FAU - McGlynn, K A
AU  - McGlynn KA
LA  - eng
GR  - Z01 CP010126-12/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110530
PL  - England
TA  - Int J Androl
JT  - International journal of andrology
JID - 8000141
RN  - Nonseminomatous germ cell tumor
SB  - IM
MH  - Clinical Coding/*statistics & numerical data
MH  - Data Interpretation, Statistical
MH  - Female
MH  - Humans
MH  - Male
MH  - Neoplasms, Germ Cell and Embryonal/*epidemiology
MH  - Pregnancy
MH  - Pregnancy Complications, Neoplastic
MH  - Registries
MH  - Testicular Neoplasms/epidemiology
PMC - PMC3145003
MID - NIHMS284222
COIS- The authors declare no conflicts of interest of financial disclosures.
EDAT- 2011/06/01 06:00
MHDA- 2012/01/20 06:00
PMCR- 2012/08/01
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2012/01/20 06:00 [medline]
PHST- 2012/08/01 00:00 [pmc-release]
AID - 10.1111/j.1365-2605.2011.01187.x [doi]
PST - ppublish
SO  - Int J Androl. 2011 Aug;34(4 Pt 2):e274-7. doi: 10.1111/j.1365-2605.2011.01187.x. 
      Epub 2011 May 30.