PMID- 21624227
OWN - NLM
STAT- MEDLINE
DCOM- 20111219
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 50
IP  - 5
DP  - 2011 May
TI  - [A study of serum cartilage oligomeric matrix protein and matrix 
      metalloproteinase-3 concentration in osteoarthritic rabbit models].
PG  - 416-9
AB  - OBJECTIVE: To study the levels of cartilage oligomeric matrix protein (COMP) and 
      matrix metalloproteinase-3 (MMP-3) in the serum fluid of osteoarthritic rabbit 
      models and their relationships with the severity of pathological changes, so as 
      to investigate their correlation with osteoarthritis (OA). METHODS: The 
      osteoarthritic animal models were get from immobilizing the right knees of 18 
      rabbits in full extension using plaster cast. Knee joint pathological changes of 
      2, 6 weeks were examined for pathological severity of OA; ELISA sandwich method 
      was used to measure the levels of COMP and MMP-3 in serum before and after 
      modeling (at 2, 6 weeks respectively); X ray of model keens was also obtained in 
      different period. Correlation analysis was performed to demonstrate the 
      relationship between the levels of COMP, MMP-3 in the serum and the pathological 
      severity of OA. RESULTS: (1) Morphological observations:immobilizing the right 
      knees of rabbits in full extension using plaster cast was a reliable method for 
      osteoarthritic animal models and the typical histopathologic character was seen; 
      the severity of osteoarthritis gradually increased with time extended. (2) The 
      levels of COMP [(3.64 +/- 0.18) microg/L], MMP-3 [(1.99 +/- 0.81) microg/L] in the serum of 2 
      weeks osteoarthritic animal models were higher than those before immobilizing 
      with plaster cast [COMP (3.35 +/- 0.20) microg/L, MMP-3 (1.61 +/- 0.71) microg/L]. The levels 
      of COMP [(3.96 +/- 0.44) microg/L], MMP-3 [(3.44 +/- 0.91) microg/L] of 6 weeks were much 
      higher, with a significant difference (P < 0.05). The levels of COMP, MMP-3 in 
      serum had a linear correlation with the pathological severity of OA (r > 0.710, 
      and P < 0.05). CONCLUSION: The levels of COMP and MMP-3 in serum can help to 
      predict and evaluate the progression of OA.
FAU - Li, Gui-ye
AU  - Li GY
AD  - Department of Rheumatology and Immunology, China-Japan Friendship Hospital, 
      Beijing 100029, China.
FAU - Zhang, Rong-fu
AU  - Zhang RF
FAU - Pan, Lin
AU  - Pan L
FAU - Zhang, Xin
AU  - Zhang X
FAU - Zhang, Kuo
AU  - Zhang K
FAU - Wang, Guo-chun
AU  - Wang GC
FAU - Wu, Dong-hai
AU  - Wu DH
FAU - Ma, Li
AU  - Ma L
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Matrilin Proteins)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Extracellular Matrix Proteins/*blood
MH  - Glycoproteins/*blood
MH  - Male
MH  - Matrilin Proteins
MH  - Matrix Metalloproteinase 3/*blood
MH  - Osteoarthritis, Knee/*blood/pathology
MH  - Rabbits
EDAT- 2011/06/01 06:00
MHDA- 2011/12/20 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/12/20 06:00 [medline]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2011 May;50(5):416-9.