PMID- 21624435
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20211020
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 189
DP  - 2011 Aug 25
TI  - Neuroanatomic and behavioral traits for autistic disorders in age-specific 
      restricted index selection mice.
PG  - 215-22
LID - 10.1016/j.neuroscience.2011.05.017 [doi]
AB  - The pathogenesis of neurodevelopmental disorders such as autism is believed to be 
      influenced by interactions between genetic and environmental factors, and 
      appropriate animal models are needed to assess the influence of such factors on 
      relevant neurodevelopmental phenotypes. A set of inbred mouse strains (Atchley 
      strains) including A12 (E+L0) and A22 (E-L0) were generated by age-specific 
      restricted index selection from a baseline random-bred ICR mouse population 
      obtained from Harlan Sprague-Dawley [Atchley et al. (1997) Genetics 
      146(2):629-640; Indianapolis, IN, USA). As compared with the A22 strain, A12 mice 
      had significantly increased early (P0-P10) body weight gain with minimal changes 
      in late (P28-P56) body weight gain. We found that these strains also differed in 
      brain weight, brain volume, cell proliferation, and FGF-2 levels in certain brain 
      regions. Specifically, brain weight and volume were significantly greater in A12 
      mice than that in A22 mice at P10 and P28. Quantitative analysis of 
      bromodeoxyuridine (BrdU) labeling of proliferating cells showed that the number 
      of BrdU-positive cells in the A12 strain were significantly greater in the 
      frontal cortex and lesser in the dentate gyrus than that in the A22 strain at 
      P28. Western blot revealed that fibroblast growth factors-2 (FGF-2), but not 
      brain-derived neurotrophic factor (BDNF), expression was significantly increased 
      in the frontal cortex of A12 strain at P28. Also, A12 mice exhibited decreased 
      intra-strain social interaction and increased repetitive stereotyped behaviors at 
      P28. Our study suggests that A12 mice may partially mimic the anatomic and 
      behavioral traits of patients with neurodevelopmental disorders such as autism 
      spectrum disorders, and therefore may yield insights into the developmental 
      mechanisms involved in their pathogenesis.
CI  - Copyright (c) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Meng, L
AU  - Meng L
AD  - Department of Psychiatry and Behavioral Sciences, Northwestern University 
      Feinberg School of Medicine, Chicago, IL, USA.
FAU - Lu, L
AU  - Lu L
FAU - Murphy, K M
AU  - Murphy KM
FAU - Yuede, C M
AU  - Yuede CM
FAU - Cheverud, J M
AU  - Cheverud JM
FAU - Csernansky, J G
AU  - Csernansky JG
FAU - Dong, H
AU  - Dong H
LA  - eng
GR  - R01 AG025824/AG/NIA NIH HHS/United States
GR  - R01 AG025824-05/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20110526
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 103107-01-3 (Fibroblast Growth Factor 2)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Autistic Disorder/*pathology/*psychology
MH  - Brain/metabolism/*pathology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cerebral Cortex/metabolism
MH  - Disease Models, Animal
MH  - Fibroblast Growth Factor 2/metabolism
MH  - Grooming
MH  - Hippocampus/metabolism
MH  - Interpersonal Relations
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Organ Size
MH  - Species Specificity
MH  - Stereotyped Behavior
PMC - PMC3150457
MID - NIHMS304815
EDAT- 2011/06/01 06:00
MHDA- 2012/03/01 06:00
PMCR- 2012/08/25
CRDT- 2011/06/01 06:00
PHST- 2011/03/16 00:00 [received]
PHST- 2011/04/26 00:00 [revised]
PHST- 2011/05/07 00:00 [accepted]
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
PHST- 2012/08/25 00:00 [pmc-release]
AID - S0306-4522(11)00549-5 [pii]
AID - 10.1016/j.neuroscience.2011.05.017 [doi]
PST - ppublish
SO  - Neuroscience. 2011 Aug 25;189:215-22. doi: 10.1016/j.neuroscience.2011.05.017. 
      Epub 2011 May 26.