PMID- 21624746
OWN - NLM
STAT- MEDLINE
DCOM- 20110802
LR  - 20220316
IS  - 1534-4436 (Electronic)
IS  - 1081-1206 (Linking)
VI  - 106
IP  - 6
DP  - 2011 Jun
TI  - Association between genes encoding components of the IL-10/IL-0 receptor pathway 
      and asthma in children.
PG  - 474-80
LID - 10.1016/j.anai.2011.02.021 [doi]
AB  - BACKGROUND: Asthma is a chronic inflammation of the airways associated with 
      recurrent symptoms that range from mild to debilitating. Interleukin-10 (IL-10) 
      is a cytokine that displays pleiotropic effects in asthma and allergy. OBJECTIVE: 
      To determine whether polymorphisms of IL-10/IL-10R pathway contribute to asthma 
      susceptibility in Egyptian children. METHODS: The IL-10 (-1082G/A), IL-10R1 
      (G330R), and signal transducer and activator of transcription 3 (STAT3) rs2293452 
      single-nucleotide polymorphism (SNP) were genotyped in 110 atopic children with 
      asthma, 110 non-atopic children with asthma, and 110 healthy children. Serum 
      IL-10 and immunoglobulin E (IgE) levels were determined by enzyme-linked 
      immunosorbent assay. RESULTS: A significant association was observed between the 
      IL-10 polymorphism and asthma in both atopic (P = .03) and non-atopic asthma 
      groups (P = .04). The genotype frequencies of IL-10R1 polymorphisms did not 
      differ between all groups. We identified a significant association between STAT3 
      polymorphism and asthma susceptibility in atopic asthma (P < .001), whereas no 
      such association was observed in the non-atopic asthma group (P = .9). No 
      evidence of gene interactions was found. CONCLUSION: Polymorphisms of IL-10 and 
      STAT3 may be useful as a new DNA-based diagnostic biomarker for identifying 
      high-risk children susceptible to asthma.
CI  - Copyright (c) 2011 American College of Allergy, Asthma & Immunology. Published by 
      Elsevier Inc. All rights reserved.
FAU - Hussein, Yousri M
AU  - Hussein YM
AD  - Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Egypt. 
      yousrihussein@hotmail.com
FAU - Shalaby, Sally M
AU  - Shalaby SM
FAU - Mohamed, Randa H
AU  - Mohamed RH
FAU - Hassan, Tamer H
AU  - Hassan TH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110430
PL  - United States
TA  - Ann Allergy Asthma Immunol
JT  - Annals of allergy, asthma & immunology : official publication of the American 
      College of Allergy, Asthma, & Immunology
JID - 9503580
RN  - 0 (Receptors, Interleukin-10)
RN  - 0 (STAT3 Transcription Factor)
RN  - 130068-27-8 (Interleukin-10)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/*genetics/*immunology
MH  - Base Sequence
MH  - Child
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/blood/genetics
MH  - Inflammation
MH  - Interleukin-10/blood/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, Interleukin-10/*genetics
MH  - Risk Factors
MH  - STAT3 Transcription Factor/*genetics
MH  - Sequence Analysis, DNA
MH  - Signal Transduction
EDAT- 2011/06/01 06:00
MHDA- 2011/08/04 06:00
CRDT- 2011/06/01 06:00
PHST- 2010/12/07 00:00 [received]
PHST- 2011/02/12 00:00 [revised]
PHST- 2011/02/25 00:00 [accepted]
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/08/04 06:00 [medline]
AID - S1081-1206(11)00157-8 [pii]
AID - 10.1016/j.anai.2011.02.021 [doi]
PST - ppublish
SO  - Ann Allergy Asthma Immunol. 2011 Jun;106(6):474-80. doi: 
      10.1016/j.anai.2011.02.021. Epub 2011 Apr 30.