PMID- 21625415
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 4
DP  - 2011
TI  - Dendritic cell populations in patients with self-reported food hypersensitivity.
PG  - 389-96
LID - 10.2147/IJGM.S17655 [doi]
AB  - Self-reported hypersensitivity to food is a common condition and many of these 
      patients have indications of intestinal immune activation. Dendritic cells (DCs) 
      are recognized as the most potent antigen-presenting cells involved in both 
      initiating immune responses and maintaining tolerance. The aims of this study 
      were to evaluate the DC populations with their phenotype and T cell stimulatory 
      capacity in patients with food hypersensitivity and to study its relationship 
      with atopic disease. Blood samples from 10 patients with self-reported food 
      hypersensitivity, divided into atopic and nonatopic subgroups, and 10 gender- and 
      age-matched healthy controls were analyzed by flow cytometry using the Miltenyi 
      Blood Dendritic cells kit. Monocyte-derived DCs (moDCs) were evaluated concerning 
      their phenotype and T cell stimulatory capacity. DC populations and cell surface 
      markers were not significantly different between patients and healthy controls, 
      but moDCs from atopic patients expressed significantly more CD38 compared to 
      moDCs from nonatopic patients. Moreover, lipopolysaccharide stimulated moDCs from 
      atopic patients produced significantly more interleukin-10 compared to nonatopic 
      patients. CD38 expression was correlated to total serum immunoglobulin E levels. 
      These findings support the notion of immune activation in some patients with 
      self-reported food hypersensitivity. They need to be confirmed in a larger 
      cohort.
FAU - Lied, Gulen A
AU  - Lied GA
AD  - Institute of Medicine.
FAU - Vogelsang, Petra
AU  - Vogelsang P
FAU - Berstad, Arnold
AU  - Berstad A
FAU - Appel, Silke
AU  - Appel S
LA  - eng
PT  - Journal Article
DEP - 20110515
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC3100221
OTO - NOTNLM
OT  - CD38
OT  - atopy
OT  - dendritic cells
OT  - food hypersensitivity
EDAT- 2011/06/01 06:00
MHDA- 2011/06/01 06:01
PMCR- 2011/05/15
CRDT- 2011/06/01 06:00
PHST- 2011/05/13 00:00 [received]
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/06/01 06:01 [medline]
PHST- 2011/05/15 00:00 [pmc-release]
AID - ijgm-4-389 [pii]
AID - 10.2147/IJGM.S17655 [doi]
PST - ppublish
SO  - Int J Gen Med. 2011;4:389-96. doi: 10.2147/IJGM.S17655. Epub 2011 May 15.