PMID- 21625828
OWN - NLM
STAT- MEDLINE
DCOM- 20110920
LR  - 20191112
IS  - 1868-8551 (Electronic)
IS  - 1868-596X (Linking)
VI  - 28
IP  - 2
DP  - 2011
TI  - Local lymph node assay: how testing laboratories apply OECD TG 429 for REACH 
      purposes.
PG  - 117-29
AB  - The Local Lymph Node Assay (LLNA) is the official method for assessing the 
      allergic contact dermatitis potential of chemicals for the purposes of REACH 
      regulation. The LLNA went through a validation process that allowed the 
      delineation of a robust protocol for performing new tests. The OECD accepted this 
      method in 2002 and published OECD TG 429. The European Chemical Agency (ECHA) 
      recently published data that were submitted in the registration dossiers of 
      chemicals. This database was analysed to determine how testing laboratories apply 
      OECD TG 429. This analysis comes after a detailed analysis of four full study 
      reports that were also prepared for REACH purposes. Although the majority of the 
      tests are fully compliant with OECD TG 429, some showed major deviations, and a 
      number of others used more animals than necessary. This suggests that in vivo 
      tests need to be planned more carefully and consciously to obtain meaningful 
      results with the minimum animal number necessary.
FAU - Rovida, Costanza
AU  - Rovida C
AD  - CAAT-Europe, University of Konstanz, Germany. costanza.rovida@chimici.it
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - ALTEX
JT  - ALTEX
JID - 100953980
SB  - IM
MH  - Animal Testing Alternatives/*methods/standards
MH  - Animal Welfare
MH  - Animals
MH  - Consumer Product Safety/legislation & jurisprudence
MH  - *European Union
MH  - Female
MH  - *Local Lymph Node Assay
MH  - Mice
MH  - Pilot Projects
MH  - Risk Assessment/methods
EDAT- 2011/06/01 06:00
MHDA- 2011/09/21 06:00
CRDT- 2011/06/01 06:00
PHST- 2011/06/01 06:00 [entrez]
PHST- 2011/06/01 06:00 [pubmed]
PHST- 2011/09/21 06:00 [medline]
AID - 10.14573/altex.2011.2.117 [doi]
PST - ppublish
SO  - ALTEX. 2011;28(2):117-29. doi: 10.14573/altex.2011.2.117.