PMID- 21627652
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20211020
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 133
IP  - 4
DP  - 2011 Aug
TI  - Complexity of dendritic cell subsets and their function in the host immune 
      system.
PG  - 409-19
LID - 10.1111/j.1365-2567.2011.03457.x [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that are critical 
      for induction of adaptive immunity and tolerance. Traditionally DCs have been 
      divided into two discrete subtypes, which comprise conventional and 
      non-conventional DCs. They are distributed across various organs in the body and 
      comprise a heterogeneous population, which has been shown to display differences 
      in terms of surface marker expression, function and origins. Recent studies have 
      shed new light on the process of DC differentiation and distribution of DC 
      subtypes in various organs. Although monocytes, macrophages and DCs share a 
      common macrophage-DC progenitor, a common DC progenitor population has been 
      identified that exclusively gives rise to DCs and not monocytes or macrophages. 
      In this review, we discuss the recent advances in our understanding of DC 
      differentiation and subtypes and provide a comprehensive overview of various DC 
      subtypes with emphasis on their function and origins. Furthermore, in light of 
      recent developments in the field of DC biology, we classify DCs based on the 
      precursor populations from which the various DC subsets originate. We classify 
      DCs derived from common DC progenitor and pre-DC populations as conventional DCs, 
      which includes both migratory and lymphoid-resident DC subsets and classify 
      monocyte-derived DCs and plasmacytoid DCs as non-conventional DCs.
CI  - (c) 2011 The Authors. Immunology (c) 2011 Blackwell Publishing Ltd.
FAU - Kushwah, Rahul
AU  - Kushwah R
AD  - Physiology and Experimental Medicine Research Program, Hospital for Sick 
      Children, Toronto, ON, Canada.
FAU - Hu, Jim
AU  - Hu J
LA  - eng
GR  - Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110601
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Dendritic Cells/*cytology/*immunology
MH  - Humans
MH  - Immune System/*immunology
PMC - PMC3143352
EDAT- 2011/06/02 06:00
MHDA- 2011/09/09 06:00
PMCR- 2012/08/01
CRDT- 2011/06/02 06:00
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
PHST- 2012/08/01 00:00 [pmc-release]
AID - 10.1111/j.1365-2567.2011.03457.x [doi]
PST - ppublish
SO  - Immunology. 2011 Aug;133(4):409-19. doi: 10.1111/j.1365-2567.2011.03457.x. Epub 
      2011 Jun 1.