PMID- 21628107
OWN - NLM
STAT- MEDLINE
DCOM- 20120113
LR  - 20231213
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 119
IP  - 9
DP  - 2011 Sep
TI  - Thirdhand tobacco smoke: emerging evidence and arguments for a multidisciplinary 
      research agenda.
PG  - 1218-26
LID - 10.1289/ehp.1103500 [doi]
AB  - BACKGROUND: There is broad consensus regarding the health impact of tobacco use 
      and secondhand smoke exposure, yet considerable ambiguity exists about the nature 
      and consequences of thirdhand smoke (THS). OBJECTIVES: We introduce definitions 
      of THS and THS exposure and review recent findings about constituents, indoor 
      sorption-desorption dynamics, and transformations of THS; distribution and 
      persistence of THS in residential settings; implications for pathways of 
      exposure; potential clinical significance and health effects; and behavioral and 
      policy issues that affect and are affected by THS. DISCUSSION: Physical and 
      chemical transformations of tobacco smoke pollutants take place over time scales 
      ranging from seconds to months and include the creation of secondary pollutants 
      that in some cases are more toxic (e.g., tobacco-specific nitrosamines). THS 
      persists in real-world residential settings in the air, dust, and surfaces and is 
      associated with elevated levels of nicotine on hands and cotinine in urine of 
      nonsmokers residing in homes previously occupied by smokers. Much still needs to 
      be learned about the chemistry, exposure, toxicology, health risks, and policy 
      implications of THS. CONCLUSION: The existing evidence on THS provides strong 
      support for pursuing a programmatic research agenda to close gaps in our current 
      understanding of the chemistry, exposure, toxicology, and health effects of THS, 
      as well as its behavioral, economic, and sociocultural considerations and 
      consequences. Such a research agenda is necessary to illuminate the role of THS 
      in existing and future tobacco control efforts to decrease smoking initiation and 
      smoking levels, to increase cessation attempts and sustained cessation, and to 
      reduce the cumulative effects of tobacco use on morbidity and mortality.
FAU - Matt, Georg E
AU  - Matt GE
AD  - Department of Psychology, San Diego State University, San Diego, CA 92182, USA. 
      gmatt@sciences.sdsu.edu
FAU - Quintana, Penelope J E
AU  - Quintana PJ
FAU - Destaillats, Hugo
AU  - Destaillats H
FAU - Gundel, Lara A
AU  - Gundel LA
FAU - Sleiman, Mohamad
AU  - Sleiman M
FAU - Singer, Brett C
AU  - Singer BC
FAU - Jacob, Peyton
AU  - Jacob P
FAU - Benowitz, Neal
AU  - Benowitz N
FAU - Winickoff, Jonathan P
AU  - Winickoff JP
FAU - Rehan, Virender
AU  - Rehan V
FAU - Talbot, Prue
AU  - Talbot P
FAU - Schick, Suzaynn
AU  - Schick S
FAU - Samet, Jonathan
AU  - Samet J
FAU - Wang, Yinsheng
AU  - Wang Y
FAU - Hang, Bo
AU  - Hang B
FAU - Martins-Green, Manuela
AU  - Martins-Green M
FAU - Pankow, James F
AU  - Pankow JF
FAU - Hovell, Melbourne F
AU  - Hovell MF
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110531
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Air Pollutants)
RN  - 0 (Nitrosamines)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 6M3C89ZY6R (Nicotine)
RN  - K5161X06LL (Cotinine)
SB  - IM
CIN - Environ Health Perspect. 2011 Sep;119(9):a399. PMID: 21885371
MH  - Air Pollutants/*chemistry/*toxicity
MH  - Air Pollution, Indoor/adverse effects/prevention & control
MH  - Cotinine/analysis/toxicity
MH  - Drug Evaluation
MH  - *Environmental Exposure
MH  - Health Policy
MH  - Humans
MH  - Nicotine/analysis/toxicity
MH  - Nitrosamines/analysis/toxicity
MH  - Nicotiana/*chemistry/*toxicity
MH  - Tobacco Smoke Pollution/*adverse effects/prevention & control
PMC - PMC3230406
COIS- FAMRI had no role in the design, conduct, interpretation or publication of the 
      research, and the organization does not gain or lose financially through 
      publication of any article. The other authors declare they have no actual or 
      potential competing financial interests.
EDAT- 2011/06/02 06:00
MHDA- 2012/01/14 06:00
PMCR- 2011/09/01
CRDT- 2011/06/02 06:00
PHST- 2011/01/28 00:00 [received]
PHST- 2011/05/31 00:00 [accepted]
PHST- 2011/06/02 06:00 [entrez]
PHST- 2011/06/02 06:00 [pubmed]
PHST- 2012/01/14 06:00 [medline]
PHST- 2011/09/01 00:00 [pmc-release]
AID - ehp.1103500 [pii]
AID - 10.1289/ehp.1103500 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2011 Sep;119(9):1218-26. doi: 10.1289/ehp.1103500. Epub 
      2011 May 31.