PMID- 2163063
OWN - NLM
STAT- MEDLINE
DCOM- 19900727
LR  - 20190907
IS  - 0278-5846 (Print)
IS  - 0278-5846 (Linking)
VI  - 14
IP  - 3
DP  - 1990
TI  - Effects of lithium on an amphetamine animal model of bipolar disorder.
PG  - 347-58
AB  - 1. This study examines the effects of chronic lithium administration on changes 
      induced by amphetamine administration and withdrawal on open field locomotor 
      activity of rats, and considered as an animal model of behaviors displayed in 
      bipolar disorders. 2. For 21 days, rats were administered either single daily 
      intraperitoneal injections (IP) of 0.9% saline, 0.15 mEq/kg, or 1.5 mEq/kg 
      lithium chloride (LiCl). From day 7 to day 16, half of the animals in each group 
      consisting of 12 rats were administered twice daily IP injections of either 1.5 
      mg/kg d-amphetamine or 0.9% saline. From day 17 to 21, d-amphetamine was 
      withdrawn. 3. Neither dose of LiCl significantly altered the increases in 
      activity levels produced by amphetamine. The withdrawal of amphetamine lead to an 
      immediate return to baseline activity levels which neither dose of LiCl 
      significantly affected. 4. The absence of interactive effects suggests that the 
      influence of lithium and amphetamine on activity are mediated by different 
      neurotransmitter systems.
FAU - Cappeliez, P
AU  - Cappeliez P
AD  - School of Psychology, University of Ottawa, Canada.
FAU - Moore, E
AU  - Moore E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Chlorides)
RN  - 9FN79X2M3F (Lithium)
RN  - G4962QA067 (Lithium Chloride)
RN  - TZ47U051FI (Dextroamphetamine)
SB  - IM
MH  - Animals
MH  - Bipolar Disorder/chemically induced/*drug therapy
MH  - Chlorides/*therapeutic use
MH  - Dextroamphetamine/*toxicity
MH  - Disease Models, Animal
MH  - Lithium/*therapeutic use
MH  - Lithium Chloride
MH  - Male
MH  - Motor Activity/drug effects
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
MH  - Substance Withdrawal Syndrome
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1016/0278-5846(90)90023-a [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(3):347-58. doi: 
      10.1016/0278-5846(90)90023-a.