PMID- 21631413
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20190923
IS  - 1875-5402 (Electronic)
IS  - 1386-2073 (Linking)
VI  - 14
IP  - 9
DP  - 2011 Nov
TI  - Essential attributes identified in the design of a Laboratory Information 
      Management System for a high throughput siRNA screening laboratory.
PG  - 766-71
AB  - In recent years high throughput screening operations have become a critical 
      application in functional and translational research. Although a seemingly 
      unmanageable amount of data is generated by these high-throughput, large-scale 
      techniques, through careful planning, an effective Laboratory Information 
      Management System (LIMS) can be developed and implemented in order to streamline 
      all phases of a workflow. Just as important as data mining and analysis 
      procedures at the end of complex processes is the tracking of individual steps of 
      applications that generate such data. Ultimately, the use of a customized LIMS 
      will enable users to extract meaningful results from large datasets while 
      trusting the robustness of their assays. To illustrate the design of a custom 
      LIMS, this practical example is provided to highlight the important aspects of 
      the design of a LIMS to effectively modulate all aspects of an siRNA screening 
      service. This system incorporates inventory management, control of workflow, data 
      handling and interaction with investigators, statisticians and administrators. 
      All these modules are regulated in a synchronous manner within the LIMS.
CI  - (c) 2011 Bentham Science Publishers
FAU - Grandjean, Geoffrey
AU  - Grandjean G
AD  - Department of Experimental Therapeutics, The University of Texas M.D. Anderson 
      Cancer Center, Houston, TX 77030, USA. gvgrandj@mdanderson.org
FAU - Graham, Ryan
AU  - Graham R
FAU - Bartholomeusz, Geoffrey
AU  - Bartholomeusz G
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Comb Chem High Throughput Screen
JT  - Combinatorial chemistry & high throughput screening
JID - 9810948
RN  - 0 (RNA, Small Interfering)
SB  - IM
MH  - *Clinical Laboratory Information Systems
MH  - Computer Security
MH  - Equipment and Supplies
MH  - *RNA, Small Interfering
EDAT- 2011/06/03 06:00
MHDA- 2012/03/28 06:00
CRDT- 2011/06/03 06:00
PHST- 2010/12/04 00:00 [received]
PHST- 2011/03/22 00:00 [revised]
PHST- 2011/04/12 00:00 [accepted]
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
AID - BSP/CCHTS/E- Pub/00188 [pii]
AID - 10.2174/138620711796957152 [doi]
PST - ppublish
SO  - Comb Chem High Throughput Screen. 2011 Nov;14(9):766-71. doi: 
      10.2174/138620711796957152.