PMID- 21631415
OWN - NLM
STAT- MEDLINE
DCOM- 20120327
LR  - 20211020
IS  - 1875-5402 (Electronic)
IS  - 1386-2073 (Print)
IS  - 1386-2073 (Linking)
VI  - 14
IP  - 9
DP  - 2011 Nov
TI  - Challenges in small screening laboratories: implementing an on-demand laboratory 
      information management system.
PG  - 742-8
AB  - The Miami Project to Cure Paralysis, part of the University of Miami Miller 
      School of Medicine, includes a laboratory devoted to High Content Analysis (HCA) 
      of neurons. The goal of the laboratory is to uncover signaling pathways, genes, 
      compounds, or drugs that can be used to promote nerve growth. HCA permits the 
      quantification of neuronal morphology, including the lengths and numbers of 
      axons. HCA of various libraries on primary neurons requires a team-based 
      approach, a variety of process steps and complex manipulations of cells and 
      libraries to obtain meaningful results. HCA itself produces vast amounts of 
      information including images, well-based data and cell-based phenotypic measures. 
      Documenting and integrating the experimental workflows, library data and 
      extensive experimental results is challenging. For academic laboratories 
      generating large data sets from experiments involving thousands of perturbagens, 
      a Laboratory Information Management System (LIMS) is the data tracking solution 
      of choice. With both productivity and efficiency as driving rationales, the Miami 
      Project has equipped its HCA laboratory with an On Demand or Software As A 
      Service (SaaS) LIMS to ensure the quality of its experiments and workflows. The 
      article discusses how the system was selected and integrated into the laboratory. 
      The advantages of a SaaS based LIMS over a client-server based system are 
      described.
CI  - (c) 2011 Bentham Science Publishers
FAU - Lemmon, Vance P
AU  - Lemmon VP
AD  - Miami Project to Cure Paralysis, Center for Computational Sciences, John P. 
      Hussman Institute for Human Genomics University of Miami Miller School of 
      Medicine, 1095 NW 14th Ter., LPLC, Rm 4-16 R-48, Miami, Fl 33136-1060, USA. 
      vlemmon@med.miami.edu
FAU - Jia, Yuanyuan
AU  - Jia Y
FAU - Shi, Yan
AU  - Shi Y
FAU - Holbrook, S Douglas
AU  - Holbrook SD
FAU - Bixby, John L
AU  - Bixby JL
FAU - Buchser, William
AU  - Buchser W
LA  - eng
GR  - R01 HD057632/HD/NICHD NIH HHS/United States
GR  - NS069488/NS/NINDS NIH HHS/United States
GR  - RC2 HG005668/HG/NHGRI NIH HHS/United States
GR  - RC2 HG005668-01/HG/NHGRI NIH HHS/United States
GR  - RC2 NS069488-01/NS/NINDS NIH HHS/United States
GR  - R01 NS059866/NS/NINDS NIH HHS/United States
GR  - R01 NS059866-03/NS/NINDS NIH HHS/United States
GR  - NS059866/NS/NINDS NIH HHS/United States
GR  - HG005668/HG/NHGRI NIH HHS/United States
GR  - RC2 NS069488/NS/NINDS NIH HHS/United States
GR  - R01 HD057632-03/HD/NICHD NIH HHS/United States
GR  - HD057521/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United Arab Emirates
TA  - Comb Chem High Throughput Screen
JT  - Combinatorial chemistry & high throughput screening
JID - 9810948
SB  - IM
MH  - *Clinical Laboratory Information Systems
MH  - Humans
MH  - Laboratories/*organization & administration
MH  - Paralysis/therapy
PMC - PMC3289069
MID - NIHMS358403
COIS- Conflict of Interest: The LemBix lab is a beta site for Thermo Fisher Scientific 
      Nautilus LIMS-on-Demand. Doug Holbrook is an employee of Thermo Fisher 
      Scientific.
EDAT- 2011/06/03 06:00
MHDA- 2012/03/28 06:00
PMCR- 2012/11/01
CRDT- 2011/06/03 06:00
PHST- 2010/10/13 00:00 [received]
PHST- 2011/02/04 00:00 [revised]
PHST- 2011/05/24 00:00 [accepted]
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2012/03/28 06:00 [medline]
PHST- 2012/11/01 00:00 [pmc-release]
AID - BSP/CCHTS/E- Pub/00186 [pii]
AID - 10.2174/138620711796957161 [doi]
PST - ppublish
SO  - Comb Chem High Throughput Screen. 2011 Nov;14(9):742-8. doi: 
      10.2174/138620711796957161.