PMID- 21631594
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20220408
IS  - 1600-0501 (Electronic)
IS  - 0905-7161 (Linking)
VI  - 23
IP  - 2
DP  - 2012 Feb
TI  - Calcium phosphate/poly(D,L-lactic-co-glycolic acid) composite bone substitute 
      materials: evaluation of temporal degradation and bone ingrowth in a rat 
      critical-sized cranial defect.
PG  - 151-159
LID - 10.1111/j.1600-0501.2011.02218.x [doi]
AB  - OBJECTIVES: The present study aimed to provide temporal information on material 
      degradation and bone formation using composite (C) bone defect filler materials 
      consisting of calcium phosphate cement (CaP) and poly(D,L-lactic-co-glycolic 
      acid) (PLGA) microparticles (20 or 30 wt%) in rat critical-sized cranial defects. 
      MATERIALS AND METHODS: Critical-sized bicortical cranial defects were created in 
      48 rats and CaP/PLGA cement composites were implanted for 4, 8 and 12 weeks 
      (n=8). RESULTS: Histological analysis of the retrieved specimens revealed that 
      implant degradation was significantly faster for C30% (remaining implant up to 
      89.4 +/- 4.4% at 12 weeks) compared with C20% (remaining implant upto 94.8 +/- 2.1% 
      at 12 weeks), albeit that overall degradation was limited. Although bone 
      formation was limited in both experimental groups (upto 685765.9 mum(2) for C20% 
      vs. 917603.3 mum(2) for C30%), C30% showed a significant temporal increase of 
      total bone formation. The percentage of defect bridging was comparable for C20% 
      and C30% at all implantation periods (range 40 +/- 25.5% at week 4 to 65 +/- 20% at 
      week 12 for C20%; range 51.8 +/- 7.8% at week 4 to 70.5 +/- 16.2% at week 12 for 
      C30%). CONCLUSION: The amount of PLGA-microparticles in the CaP/PLGA cement 
      composites demonstrated acceleration of material degradation, while bone 
      formation was found not to be influenced. Further optimization of the composite 
      material is necessary to increase control over degradation and tissue ingrowth.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - van de Watering, Floor C J
AU  - van de Watering FCJ
AD  - Department of Biomaterials (309), Radboud University Nijmegen Medical Center, 
      Nijmegen, The Netherlands.
FAU - van den Beucken, Jeroen J J P
AU  - van den Beucken JJJP
AD  - Department of Biomaterials (309), Radboud University Nijmegen Medical Center, 
      Nijmegen, The Netherlands.
FAU - Walboomers, X Frank
AU  - Walboomers XF
AD  - Department of Biomaterials (309), Radboud University Nijmegen Medical Center, 
      Nijmegen, The Netherlands.
FAU - Jansen, John A
AU  - Jansen JA
AD  - Department of Biomaterials (309), Radboud University Nijmegen Medical Center, 
      Nijmegen, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110602
PL  - Denmark
TA  - Clin Oral Implants Res
JT  - Clinical oral implants research
JID - 9105713
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bone Substitutes)
RN  - 0 (Calcium Phosphates)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
MH  - *Absorbable Implants
MH  - Animals
MH  - Biocompatible Materials/chemistry/metabolism
MH  - Bone Regeneration/*drug effects
MH  - Bone Substitutes/chemistry/*metabolism
MH  - Calcium Phosphates/chemistry/*metabolism
MH  - Lactic Acid/chemistry/*metabolism
MH  - Male
MH  - Materials Testing
MH  - Particle Size
MH  - Polyglycolic Acid/chemistry/*metabolism
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Rats
MH  - Rats, Wistar
MH  - Skull/*metabolism/*surgery
MH  - Time Factors
MH  - X-Ray Microtomography
EDAT- 2011/06/03 06:00
MHDA- 2012/06/01 06:00
CRDT- 2011/06/03 06:00
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
AID - 10.1111/j.1600-0501.2011.02218.x [doi]
PST - ppublish
SO  - Clin Oral Implants Res. 2012 Feb;23(2):151-159. doi: 
      10.1111/j.1600-0501.2011.02218.x. Epub 2011 Jun 2.