PMID- 21632064
OWN - NLM
STAT- MEDLINE
DCOM- 20110830
LR  - 20220409
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Print)
IS  - 0022-3956 (Linking)
VI  - 45
IP  - 7
DP  - 2011 Jul
TI  - The treatment of minor depression with St. John's Wort or citalopram: failure to 
      show benefit over placebo.
PG  - 931-41
LID - 10.1016/j.jpsychires.2011.05.001 [doi]
AB  - This paper presents new data addressing two important controversies in 
      psychiatry: the construct of Minor Depression (MinD) and the efficacy of St. 
      John's Wort for milder forms of depressive disorders. Data are from a three-arm, 
      12 week, randomized clinical trial of investigating the efficacy of St. John's 
      Wort (810 mg/day), citalopram (20 mg/day), or placebo for acute treatment of 
      MinD. Due to a high placebo response on all outcome measures, neither St. John's 
      Wort nor citalopram separated from placebo on change in depressive symptom 
      severity, quality of life, or well-being. However, systematic assessment of 
      potential adverse effects (AEs) led to three important observations: (1) prior to 
      the administration of study compound, 60% of subjects endorsed items that would 
      be characterized as AEs once study compound was administered, (2) St. John's Wort 
      and citalopram were each associated with a significant number of new or worsening 
      AEs during treatment, and (3) using a structured interview for identifying AEs at 
      baseline and during treatment is informative. MinD was not responsive to either a 
      conventional antidepressant or a nutraceutical, and both compounds were 
      associated with a notable side effects burden. Other treatment approaches for 
      MinD should be investigated.
CI  - Copyright (c) 2011 Elsevier Ltd. All rights reserved.
FAU - Rapaport, Mark Hyman
AU  - Rapaport MH
AD  - Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical 
      Center, Los Angeles, CA 90048, USA. mark.rapaport@cshs.org
FAU - Nierenberg, Andrew A
AU  - Nierenberg AA
FAU - Howland, Robert
AU  - Howland R
FAU - Dording, Christina
AU  - Dording C
FAU - Schettler, Pamela J
AU  - Schettler PJ
FAU - Mischoulon, David
AU  - Mischoulon D
LA  - eng
GR  - R01 MH061757/MH/NIMH NIH HHS/United States
GR  - R01 MH061757-05/MH/NIMH NIH HHS/United States
GR  - 5R0-1MH61757/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20110531
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Antidepressive Agents)
RN  - 0 (Plant Extracts)
RN  - 0DHU5B8D6V (Citalopram)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antidepressive Agents/adverse effects/*therapeutic use
MH  - Citalopram/adverse effects/*therapeutic use
MH  - Depressive Disorder/*drug therapy/psychology
MH  - Female
MH  - Humans
MH  - *Hypericum
MH  - Male
MH  - Middle Aged
MH  - *Phytotherapy
MH  - Plant Extracts/adverse effects/*therapeutic use
MH  - Quality of Life/psychology
MH  - Young Adult
PMC - PMC3137264
MID - NIHMS296744
EDAT- 2011/06/03 06:00
MHDA- 2011/08/31 06:00
PMCR- 2012/07/01
CRDT- 2011/06/03 06:00
PHST- 2011/02/02 00:00 [received]
PHST- 2011/04/08 00:00 [revised]
PHST- 2011/05/05 00:00 [accepted]
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/08/31 06:00 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - S0022-3956(11)00097-5 [pii]
AID - 10.1016/j.jpsychires.2011.05.001 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2011 Jul;45(7):931-41. doi: 10.1016/j.jpsychires.2011.05.001. 
      Epub 2011 May 31.