PMID- 21632975
OWN - NLM
STAT- MEDLINE
DCOM- 20111017
LR  - 20220330
IS  - 1460-2377 (Electronic)
IS  - 0953-8178 (Print)
IS  - 0953-8178 (Linking)
VI  - 23
IP  - 7
DP  - 2011 Jul
TI  - An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 
      cell differentiation.
PG  - 415-20
LID - 10.1093/intimm/dxr029 [doi]
AB  - CD4 T(h) are critical for orchestrating adaptive immune responses. The expression 
      of the transcription factor GATA3 (GATA-binding protein 3) is up-regulated or 
      down-regulated during T(h)2 or T(h)1 cell differentiation, respectively. 
      Furthermore, GATA3 is responsible for induction of T(h)2 differentiation and 
      represses T(h)1 differentiation. In this review, we present an updated view on 
      the molecular mechanisms through which GATA3 regulates T(h)1/T(h)2 
      differentiation. During T(h)2 cell differentiation, GATA3 directly binds to the 
      T(h)2 cytokine gene locus at several regions and regulates expression. On the 
      other hand, GATA3 inhibits T(h)1 cell differentiation by preventing up-regulation 
      of IL-12 receptor beta2 and STAT4 (signal transducer and activator of transcription 
      4) and neutralization of Runx3 (runt-related transcription factor 3) function 
      through protein-protein interaction. GATA3 may also directly act on the Ifng 
      gene. In summary, GATA3 serves as a transcriptional activator or repressor 
      through direct action on transcriptional machinery and/or affecting chromatin 
      remodeling at many critical loci encoding cytokines, cytokine receptors, 
      signaling molecules as well as transcription factors that are involved in the 
      regulation of T(h)1 and T(h)2 differentiation.
FAU - Yagi, Ryoji
AU  - Yagi R
AD  - Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, 
      National Institutes of Health, Bethesda, MD 20892, USA.
FAU - Zhu, Jinfang
AU  - Zhu J
FAU - Paul, William E
AU  - Paul WE
LA  - eng
GR  - ZIA AI001169-01/ImNIH/Intramural NIH HHS/United States
GR  - 1ZIAAI000493-24/PHS HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20110601
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (Cytokines)
RN  - 0 (GATA3 Transcription Factor)
SB  - IM
MH  - Animals
MH  - Cell Differentiation/*immunology
MH  - Cytokines/genetics/immunology
MH  - GATA3 Transcription Factor/genetics/*immunology
MH  - Gene Expression Regulation/immunology
MH  - Humans
MH  - Th1 Cells/*cytology/*immunology
MH  - Th2 Cells/*cytology/*immunology
PMC - PMC3123974
EDAT- 2011/06/03 06:00
MHDA- 2011/10/18 06:00
PMCR- 2012/07/01
CRDT- 2011/06/03 06:00
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/10/18 06:00 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - dxr029 [pii]
AID - 10.1093/intimm/dxr029 [doi]
PST - ppublish
SO  - Int Immunol. 2011 Jul;23(7):415-20. doi: 10.1093/intimm/dxr029. Epub 2011 Jun 1.