PMID- 21633634
OWN - NLM
STAT- MEDLINE
DCOM- 20111013
LR  - 20211020
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 17
IP  - 19
DP  - 2011 May 21
TI  - Targeting voltage-gated sodium channels for treatment for chronic visceral pain.
PG  - 2357-64
LID - 10.3748/wjg.v17.i19.2357 [doi]
AB  - Voltage-gated sodium channels (VGSCs) play a fundamental role in controlling 
      cellular excitability, and their abnormal activity is related to several 
      pathological processes, including cardiac arrhythmias, epilepsy, 
      neurodegenerative diseases, spasticity and chronic pain. In particular, chronic 
      visceral pain, the central symptom of functional gastrointestinal disorders such 
      as irritable bowel syndrome, is a serious clinical problem that affects a high 
      percentage of the world population. In spite of intense research efforts and 
      after the dedicated decade of pain control and research, there are not many 
      options to treat chronic pain conditions. However, there is a wealth of evidence 
      emerging to give hope that a more refined approach may be achievable. By using 
      electronic databases, available data on structural and functional properties of 
      VGSCs in chronic pain, particularly functional gastrointestinal hypersensitivity, 
      were reviewed. We summarize the involvement and molecular bases of action of 
      VGSCs in the pathophysiology of several organic and functional gastrointestinal 
      disorders. We also describe the efficacy of VGSC blockers in the treatment of 
      these neurological diseases, and outline future developments that may extend the 
      therapeutic use of compounds that target VGSCs. Overall, clinical and 
      experimental data indicate that isoform-specific blockers of these channels or 
      targeting of their modulators may provide effective and novel approaches for 
      visceral pain therapy.
FAU - Qi, Fei-Hu
AU  - Qi FH
AD  - Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, 
      Jiangsu Province, China.
FAU - Zhou, You-Lang
AU  - Zhou YL
FAU - Xu, Guang-Yin
AU  - Xu GY
LA  - eng
GR  - R21 AT005158/AT/NCCIH NIH HHS/United States
GR  - AT005158/AT/NCCIH NIH HHS/United States
PT  - Editorial
PT  - Research Support, N.I.H., Extramural
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Sodium Channel Blockers)
RN  - 0 (Sodium Channels)
SB  - IM
MH  - Abdominal Pain/*drug therapy
MH  - Chronic Disease
MH  - Humans
MH  - Neuroglia/metabolism
MH  - Sensory Receptor Cells/metabolism
MH  - Sodium Channel Blockers/*pharmacology/*therapeutic use
MH  - Sodium Channels/*drug effects/metabolism
MH  - Treatment Outcome
MH  - Viscera/innervation
PMC - PMC3103787
OTO - NOTNLM
OT  - Dorsal root ganglion
OT  - Functional gastrointestinal disorders
OT  - Treatment
OT  - Visceral pain
OT  - Voltage-gated sodium channel
EDAT- 2011/06/03 06:00
MHDA- 2011/10/14 06:00
PMCR- 2011/05/21
CRDT- 2011/06/03 06:00
PHST- 2010/12/14 00:00 [received]
PHST- 2011/03/16 00:00 [revised]
PHST- 2011/03/23 00:00 [accepted]
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2011/10/14 06:00 [medline]
PHST- 2011/05/21 00:00 [pmc-release]
AID - 10.3748/wjg.v17.i19.2357 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2011 May 21;17(19):2357-64. doi: 10.3748/wjg.v17.i19.2357.