PMID- 21633892
OWN - NLM
STAT- MEDLINE
DCOM- 20120501
LR  - 20211020
IS  - 1573-4978 (Electronic)
IS  - 0301-4851 (Linking)
VI  - 39
IP  - 2
DP  - 2012 Feb
TI  - A meta-analysis on the association between three promoter variants of TNF-alpha and 
      Crohn's disease.
PG  - 1575-83
LID - 10.1007/s11033-011-0896-x [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) has been regarded as a candidate gene for 
      Crohn's disease (CD) based on its inflammatory function in immune reaction and 
      the clinical effectiveness of anti-TNF-alpha therapy. However, studies to date have 
      reported inconsistent findings for the association between TNF-alpha and CD. The 
      PubMed, EMBASE, and Medline databases were systematically reviewed from all 
      English language publications up to April, 2011. A total of twenty-nine studies 
      concerning the association between CD and the TNF-alpha promoter polymorphisms of 
      -308G/A, -857C/T and -238G/A were identified, among of them only twenty-three 
      studies match the inclusion criteria (including 3,843 cases and 6,260 controls) 
      and were selected for the statistical test. We found that neither the G allele of 
      -308G/A (OR 1.02, 95% CI 0.87-1.19, P = 0.84), C allele of -857C/T (OR 0.97, 95% 
      CI 0.86-1.09, P = 0.57) and G allele of -238G/A (OR 0.91, 95% CI 0.70-1.18, P = 
      0.48), and nor their GG (OR 1.05, 95% CI 0.88-1.25, P = 0.59), CC (OR 0.98, 95% 
      CI 0.86-1.12, P = 0.76) and GG (OR 0.92, 95% CI 0.70-1.21, P = 0.55) genotypes 
      were associated with CD susceptibility, respectively. Our meta-analysis 
      demonstrates that three promoter polymorphisms of TNF-alpha above may not confer 
      susceptibility to CD.
FAU - Xie, Cui
AU  - Xie C
AD  - Laboratory of Disorder Genes and Department of Pharmacology, College of Pharmacy, 
      Chongqing Medical University, 1 Yi Xue Yuan Road, P. O. Box 380, Chongqing 
      400016, People's Republic of China.
FAU - Liu, Xiao Feng
AU  - Liu XF
FAU - Yang, Mao Sheng
AU  - Yang MS
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20110603
PL  - Netherlands
TA  - Mol Biol Rep
JT  - Molecular biology reports
JID - 0403234
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Crohn Disease/*epidemiology/*genetics
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease/*genetics
MH  - Humans
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Promoter Regions, Genetic/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2011/06/03 06:00
MHDA- 2012/05/02 06:00
CRDT- 2011/06/03 06:00
PHST- 2011/02/21 00:00 [received]
PHST- 2011/05/17 00:00 [accepted]
PHST- 2011/06/03 06:00 [entrez]
PHST- 2011/06/03 06:00 [pubmed]
PHST- 2012/05/02 06:00 [medline]
AID - 10.1007/s11033-011-0896-x [doi]
PST - ppublish
SO  - Mol Biol Rep. 2012 Feb;39(2):1575-83. doi: 10.1007/s11033-011-0896-x. Epub 2011 
      Jun 3.