PMID- 21637372
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 2090-1844 (Electronic)
IS  - 2090-1836 (Print)
IS  - 2090-1844 (Linking)
VI  - 2011
DP  - 2011
TI  - Gradual increase of high mobility group protein b1 in the lungs after the onset 
      of acute exacerbation of idiopathic pulmonary fibrosis.
PG  - 916486
LID - 10.1155/2011/916486 [doi]
LID - 916486
AB  - The pathogenesis of acute exacerbation of idiopathic pulmonary fibrosis (IPF) 
      remains to be elucidated. To evaluate the roles of inflammatory mediators in 
      acute exacerbation, the concentrations of high mobility group protein B1 (HMGB1), 
      a chief mediator of acute lung injury, and 18 inflammatory cytokines were 
      measured in the bronchoalveolar lavage fluid, serially sampled from seven IPF 
      patients after the onset of acute exacerbation. HMGB1 gradually increased in the 
      alveolar fluid after the onset of acute exacerbation, in positive correlation 
      with monocytes chemotactic protein-1 (MCP-1), a potent fibrogenic mediator. In 
      the lung tissues of eight IPF patients autopsied after acute exacerbation, 
      intense cytoplasmic staining for HMGB1 was observed in the alveolar epithelial 
      cells in alveolar capillary augmented lesions, where the capillary endothelial 
      cells remarkably reduced the expression of thrombomodulin, an intrinsic 
      antagonist of HMGB1. These results suggest pathogenic roles for HMGB1 and MCP-1 
      in the late phase of acute exacerbation of IPF.
FAU - Ebina, Masahito
AU  - Ebina M
AD  - Department of Respiratory Medicine, Tohoku University Graduate School of 
      Medicine, 1-1 Seiryo, Aoba-ku, Sendai 980-8574, Japan.
FAU - Taniguchi, Hiroyuki
AU  - Taniguchi H
FAU - Miyasho, Taku
AU  - Miyasho T
FAU - Yamada, Shingo
AU  - Yamada S
FAU - Shibata, Naoko
AU  - Shibata N
FAU - Ohta, Hiromitsu
AU  - Ohta H
FAU - Hisata, Shu
AU  - Hisata S
FAU - Ohkouchi, Shinya
AU  - Ohkouchi S
FAU - Tamada, Tsutomu
AU  - Tamada T
FAU - Nishimura, Hidekazu
AU  - Nishimura H
FAU - Ishizaka, Akitoshi
AU  - Ishizaka A
FAU - Maruyama, Ikuro
AU  - Maruyama I
FAU - Okada, Yoshinori
AU  - Okada Y
FAU - Takashi, Kondo
AU  - Takashi K
FAU - Nukiwa, Toshihiro
AU  - Nukiwa T
LA  - eng
PT  - Journal Article
DEP - 20110221
PL  - Egypt
TA  - Pulm Med
JT  - Pulmonary medicine
JID - 101558762
PMC - PMC3100576
EDAT- 2011/06/04 06:00
MHDA- 2011/06/04 06:01
PMCR- 2011/02/21
CRDT- 2011/06/04 06:00
PHST- 2010/08/14 00:00 [received]
PHST- 2010/12/27 00:00 [revised]
PHST- 2010/12/29 00:00 [accepted]
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2011/06/04 06:01 [medline]
PHST- 2011/02/21 00:00 [pmc-release]
AID - 10.1155/2011/916486 [doi]
PST - ppublish
SO  - Pulm Med. 2011;2011:916486. doi: 10.1155/2011/916486. Epub 2011 Feb 21.