PMID- 21637495
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1678-4685 (Electronic)
IS  - 1415-4757 (Print)
IS  - 1415-4757 (Linking)
VI  - 33
IP  - 2
DP  - 2010 Apr
TI  - Dietary carotenoid-rich oil supplementation improves exercise-induced 
      anisocytosis in runners: influences of haptoglobin, MnSOD (Val9Ala), CAT (21A/T) 
      and GPX1 (Pro198Leu) gene polymorphisms in dilutional pseudoanemia (sports 
      anemia).
PG  - 359-67
LID - 10.1590/S1415-47572010005000022 [doi]
AB  - Physical training induces beneficial adaptation, whereas exhaustive exercises 
      increase reactive oxygen-species generation, thereby causing oxidative damage in 
      plasma and erythrocytes, fractions susceptible to lipid peroxidation. Pequi 
      (Caryocar brasiliense Camb.) is a Brazilian Cerrado fruit containing a 
      carotenoid-rich oil. The aim was to investigate the effects of pequi-oil on 
      exercise-induced oxidative damage in plasma and erythrocytes, after running in 
      the same environment and undergoing weekly training under the same conditions as 
      to type, intensity and length. Evaluations were accomplished after outdoor 
      running on flat land before and after ingestion of 400 mg pequi-oil capsules for 
      14 days. Blood samples were taken after running and submitted to TBARS assay and 
      erythrogram analysis. Haptoglobin, MnSOD (Val9Ala), CAT (21A/T) and GPX1 
      (Pro198Leu) gene polymorphisms were priorly investigated, so as to estimate 
      genetic influence The reduction in erythrocytes, hemoglobin and hematocrit after 
      pequi-oil treatment was notably associated with higher plasma expansion. Except 
      for MCHC (mean corpuscular hemoglobin concentration) and RDW (red cell 
      distribution width), the results were influenced by the polymorphisms studied. 
      The best response to pequi-oil was presented by MnSOD Val/Val, CAT AA or AT 
      genotypes and the GPX1 Pro allele. The significantly lower RDW and higher MHCH 
      values were related to pequi-oil protective effects. Pequi oil, besides 
      possessing other nutritional properties, showed protective blood effects.
FAU - Miranda-Vilela, Ana L
AU  - Miranda-Vilela AL
AD  - Laboratorio de Genetica, Departamento de Genetica e Morfologia, Instituto de 
      Ciencias Biologicas, Universidade de Brasilia, Brasilia, DF Brazil.
FAU - Akimoto, Arthur K
AU  - Akimoto AK
FAU - Alves, Penha C Z
AU  - Alves PC
FAU - Pereira, Luiz C S
AU  - Pereira LC
FAU - Klautau-Guimaraes, Maria N
AU  - Klautau-Guimaraes MN
FAU - Grisolia, Cesar K
AU  - Grisolia CK
LA  - eng
PT  - Journal Article
DEP - 20100601
PL  - Brazil
TA  - Genet Mol Biol
JT  - Genetics and molecular biology
JID - 100883590
PMC - PMC3036864
OTO - NOTNLM
OT  - Caryocar brasiliense Camb.
OT  - MCH
OT  - MCHC and RDW)
OT  - haptoglobin and antioxidant enzyme polymorphisms
OT  - hematimetric indexes (MCV
OT  - hemogram
EDAT- 2010/04/01 00:00
MHDA- 2010/04/01 00:01
PMCR- 2010/04/01
CRDT- 2011/06/04 06:00
PHST- 2009/09/16 00:00 [received]
PHST- 2009/11/17 00:00 [accepted]
PHST- 2011/06/04 06:00 [entrez]
PHST- 2010/04/01 00:00 [pubmed]
PHST- 2010/04/01 00:01 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - 10.1590/S1415-47572010005000022 [doi]
PST - ppublish
SO  - Genet Mol Biol. 2010 Apr;33(2):359-67. doi: 10.1590/S1415-47572010005000022. Epub 
      2010 Jun 1.