PMID- 21638118
OWN - NLM
STAT- MEDLINE
DCOM- 20120409
LR  - 20220318
IS  - 1556-0961 (Electronic)
IS  - 1541-6933 (Print)
IS  - 1541-6933 (Linking)
VI  - 16
IP  - 1
DP  - 2012 Feb
TI  - Frequency and timing of nonconvulsive status epilepticus in comatose post-cardiac 
      arrest subjects treated with hypothermia.
PG  - 114-22
LID - 10.1007/s12028-011-9565-0 [doi]
AB  - BACKGROUND: Therapeutic hypothermia (TH) improves outcomes in comatose patients 
      resuscitated from cardiac arrest. However, nonconvulsive status epilepticus 
      (NCSE) may cause persistent coma. The frequency and timing of NCSE after cardiac 
      arrest is unknown. METHODS: Review of consecutive subjects treated with TH and 
      receiving continuous EEG (cEEG) monitoring between 8/1/2009 and 11/16/2010. 
      Demographic data, survival, and functional outcome were prospectively recorded. 
      Each cEEG file was analyzed using standard definitions to define NCSE. Data were 
      analyzed using descriptive and nonparametric statistics. RESULTS: Mean age of the 
      101 subjects was 57 years (SD 15) with most subjects being male (N = 55, 54%) and 
      experiencing out-of-hospital cardiac arrest (N = 78; 77%). Ventricular 
      fibrillation was the initial cardiac rhythm in 39 (38%). All subjects received 
      TH. Thirty subjects (30%) awoke at a median of 41 h (IQR 30, 61) after cardiac 
      arrest. A total of 29/30 (97%) subjects surviving to hospital discharge were 
      awake. Median interval from arrest to placement of cEEG was 9 h (IQR 6, 12), at 
      which time the mean temperature was 33.9 degrees C. NCSE occurred in 12 (12%) subjects. 
      In 3/12 (25%) subjects, NCSE was present when the cEEG recording began. In 4 
      subjects, NCSE occurred within 8 h of cEEG recording. One (8%) subject with NCSE 
      survived in a vegetative state. CONCLUSIONS: NCSE is common in comatose 
      post-cardiac arrest subjects receiving TH. Most seizures occur within the first 8 
      h of cEEG recording and within the first 12 h after resuscitation from cardiac 
      arrest. Outcomes are poor in those who experience NCSE.
FAU - Rittenberger, Jon C
AU  - Rittenberger JC
AD  - Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA 15261, 
      USA. rittjc@upmc.edu
FAU - Popescu, Alexandra
AU  - Popescu A
FAU - Brenner, Richard P
AU  - Brenner RP
FAU - Guyette, Francis X
AU  - Guyette FX
FAU - Callaway, Clifton W
AU  - Callaway CW
LA  - eng
GR  - KL2 RR024154/RR/NCRR NIH HHS/United States
GR  - KL2 RR024154-02/RR/NCRR NIH HHS/United States
GR  - KL2 TR000146/TR/NCATS NIH HHS/United States
GR  - UL1 TR000005/TR/NCATS NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Neurocrit Care
JT  - Neurocritical care
JID - 101156086
SB  - IM
MH  - Aged
MH  - Coma/etiology/mortality/*therapy
MH  - Electroencephalography
MH  - Female
MH  - Heart Arrest/etiology/mortality/*therapy
MH  - Humans
MH  - Hypothermia, Induced/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Out-of-Hospital Cardiac Arrest/complications/mortality/*therapy
MH  - Prospective Studies
MH  - Severity of Illness Index
MH  - Status Epilepticus/*etiology/mortality/therapy
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC3188346
MID - NIHMS303982
EDAT- 2011/06/04 06:00
MHDA- 2012/04/10 06:00
PMCR- 2013/02/01
CRDT- 2011/06/04 06:00
PHST- 2011/06/04 06:00 [entrez]
PHST- 2011/06/04 06:00 [pubmed]
PHST- 2012/04/10 06:00 [medline]
PHST- 2013/02/01 00:00 [pmc-release]
AID - 10.1007/s12028-011-9565-0 [doi]
PST - ppublish
SO  - Neurocrit Care. 2012 Feb;16(1):114-22. doi: 10.1007/s12028-011-9565-0.