PMID- 21639783
OWN - NLM
STAT- MEDLINE
DCOM- 20120112
LR  - 20211020
IS  - 1545-3251 (Electronic)
IS  - 0066-4227 (Linking)
VI  - 65
DP  - 2011
TI  - Structure and function of MARTX toxins and other large repetitive RTX proteins.
PG  - 71-90
LID - 10.1146/annurev-micro-090110-102943 [doi]
AB  - The Repeats-in-Toxins (RTX) family of proteins classically consists of cytolysins 
      and hemolysins. Over the past decade, genome sequencing revealed the existence of 
      very large members of this family. These are all repetitive proteins ranging in 
      size from 200 to 900 kDa that function as toxins or adhesins. Many are exported 
      by Type I secretion. One major new subfamily is the large repetitive RTX adhesins 
      and biofilm-associated proteins. These are characterized by 80- to 300-amino-acid 
      repeats ordered in tandem, although the sequence and number of the repeats vary 
      by protein. The second major new subfamily is the multifunctional-autoprocessing 
      RTX toxins, which are associated with cytotoxicity and pathogenesis. These 
      proteins are in turn distantly related to Yersinia hypothetical RTX proteins that 
      may autoprocess by a similar mechanism. This review discusses current knowledge 
      regarding the structure and function of these new subfamilies of RTX proteins.
FAU - Satchell, Karla J F
AU  - Satchell KJ
AD  - Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern 
      University, Chicago, Illinois 60611, USA. k-satchell@northwestern.edu
LA  - eng
GR  - R01 AI051490/AI/NIAID NIH HHS/United States
GR  - AI051490-08/AI/NIAID NIH HHS/United States
GR  - AI072461-02/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Annu Rev Microbiol
JT  - Annual review of microbiology
JID - 0372370
RN  - 0 (Bacterial Proteins)
RN  - 0 (Bacterial Toxins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Bacteria/chemistry/genetics/*metabolism
MH  - Bacterial Proteins/*chemistry/genetics/*metabolism/toxicity
MH  - Bacterial Toxins/*chemistry/genetics/*metabolism/toxicity
MH  - Humans
MH  - Molecular Sequence Data
MH  - Protein Structure, Tertiary
EDAT- 2011/06/07 06:00
MHDA- 2012/01/13 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2012/01/13 06:00 [medline]
AID - 10.1146/annurev-micro-090110-102943 [doi]
PST - ppublish
SO  - Annu Rev Microbiol. 2011;65:71-90. doi: 10.1146/annurev-micro-090110-102943.