PMID- 21639804
OWN - NLM
STAT- MEDLINE
DCOM- 20110823
LR  - 20110606
IS  - 0334-1763 (Print)
IS  - 0334-1763 (Linking)
VI  - 22
IP  - 3
DP  - 2011
TI  - BDNF-TrkB signalling in fear learning: from genetics to neural networks.
PG  - 303-15
LID - 10.1515/RNS.2011.031 [doi]
AB  - Discovering the basic mechanisms in fear encoding and expression is important in 
      many fields, including psychology, sociology, medicine, and neuroscience. 
      Effective treatment for fear-based pathology depends on understanding how fear is 
      learned and regulated. Among the molecular systems required for fear learning and 
      amygdalar synaptic plasticity, brain derived neurtrophic factor (BDNF) and its 
      high affinity receptor Ntrk2/TrkB have been shown to play essential roles. 
      Therefore, we will focus this review on three main aspects; first of all, the 
      impact of Bdnf polymorphism on fear related characteristics in humans and animal 
      models. Secondly, we will discuss BDNF-TrkB activity regulation by epigenetic, 
      transcriptional and post-translational events, and finally we will discuss 
      TrkB-BDNF signalling in fear learning. BDNF-TrkB and the signalling activated in 
      this particular form of plasticity are becoming crucial players in fear learning 
      and memory thus highlighting these molecules as potential therapeutic targets in 
      fear-related pathologies.
FAU - Musumeci, Grabiele
AU  - Musumeci G
AD  - Fondazione Santa Lucia, Instituto di Ricovero e Cura a Carattere Scientifico, 
      I-00179 Rome, Italy.
FAU - Minichiello, Liliana
AU  - Minichiello L
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Rev Neurosci
JT  - Reviews in the neurosciences
JID - 8711016
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Amygdala/*cytology/metabolism
MH  - Animals
MH  - Behavior, Animal
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Epigenomics
MH  - *Fear
MH  - Humans
MH  - Learning/*physiology
MH  - Receptor, trkB/genetics/*metabolism
MH  - Signal Transduction/*physiology
EDAT- 2011/06/07 06:00
MHDA- 2011/08/24 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/08/24 06:00 [medline]
AID - 10.1515/RNS.2011.031 [doi]
PST - ppublish
SO  - Rev Neurosci. 2011;22(3):303-15. doi: 10.1515/RNS.2011.031.