PMID- 21640188
OWN - NLM
STAT- MEDLINE
DCOM- 20120227
LR  - 20111031
IS  - 1095-9327 (Electronic)
IS  - 1044-7431 (Linking)
VI  - 48
IP  - 4
DP  - 2011 Dec
TI  - Glutamate receptor dynamics and protein interaction: lessons from the NMDA 
      receptor.
PG  - 298-307
LID - 10.1016/j.mcn.2011.05.009 [doi]
AB  - The plasticity of excitatory glutamate synapses emerged over the last decades as 
      a core cellular mechanism for the encoding and processing of various cognitive 
      functions. This property relies in part on the ability to dynamically adjust the 
      content of glutamate receptors in the postsynaptic membrane. Among these 
      receptors, NMDA receptors (NMDAR), which are composed of two obligatory GluN1 and 
      two regulatory GluN2/3 subunits, play a key role in the induction of many forms 
      of plasticity processes. Understanding how NMDAR subtypes are trafficked and 
      regulated in the synapse has thus captured considerable attention. It has emerged 
      that NMDAR synaptic content relies on an equilibrium between intracellular 
      trafficking and rapid lateral diffusion of the receptor within the synaptic area. 
      Here, we review our current understanding of NMDAR trafficking, mostly the ones 
      at the surface membrane, with a specific focus on the role of interacting 
      PDZ-containing proteins during the journey of NMDAR to and around the synaptic 
      area. The cellular and molecular lessons obtained from examining NMDAR dynamics 
      and regulation by interacting proteins appear to apply to other ionotropic 
      neurotransmitter receptors, and thus shed new light on the modulation of 
      excitatory, inhibitory, and modulatory transmission. This article is part of a 
      Special Issue entitled 'Neuronal Function'.
CI  - Copyright A(c) 2011 Elsevier Inc. All rights reserved.
FAU - Bard, Lucie
AU  - Bard L
AD  - Univ. de Bordeaux, Interdisciplinary Institute for Neuroscience, UMR 5297, 
      F-33000 Bordeaux, France.
FAU - Groc, Laurent
AU  - Groc L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110526
PL  - United States
TA  - Mol Cell Neurosci
JT  - Molecular and cellular neurosciences
JID - 9100095
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neuronal Plasticity/*physiology
MH  - Neurons/*physiology
MH  - Protein Transport/physiology
MH  - Receptors, N-Methyl-D-Aspartate/*physiology
EDAT- 2011/06/07 06:00
MHDA- 2012/03/01 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/02/26 00:00 [received]
PHST- 2011/05/17 00:00 [revised]
PHST- 2011/05/18 00:00 [accepted]
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
AID - S1044-7431(11)00115-1 [pii]
AID - 10.1016/j.mcn.2011.05.009 [doi]
PST - ppublish
SO  - Mol Cell Neurosci. 2011 Dec;48(4):298-307. doi: 10.1016/j.mcn.2011.05.009. Epub 
      2011 May 26.