PMID- 21643629
OWN - NLM
STAT- MEDLINE
DCOM- 20111101
LR  - 20220321
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 4
IP  - 5
DP  - 2011 Sep-Oct
TI  - Overexpression of DEP domain containing mTOR-interacting protein correlates with 
      poor prognosis in differentiated thyroid carcinoma.
PG  - 817-23
LID - 10.3892/mmr.2011.503 [doi]
AB  - DEP domain containing mammalian target of rapamycin (mTOR)-interacting protein 
      (DEPTOR), a recently identified mTOR-interacting protein, is a novel candidate 
      oncogene. Previous studies reveal that high DEPTOR expression is required to 
      maintain PI3K and Akt activation and to inhibit apoptosis. However, its 
      significance in differentiated thyroid carcinoma (DTC) is not yet known. The 
      present study verifies the mRNA and protein expression of DEPTOR in five cell 
      lines, DTC tissues and normal adjacent tissues. Tissue microarrays of 114 DTC 
      patients were used to detect DEPTOR protein expression. The assessment of DEPTOR 
      levels demonstrated that DEPTOR in DTC cells and tissues was significantly 
      increased compared with normal cells and adjacent normal tissues. DEPTOR protein 
      expression was significantly associated with lymph node status, extrathyroid 
      extension and distant metastasis. Patients exhibiting high DEPTOR expression were 
      statistically susceptible to earlier recurrence and poorer survival than those 
      with low expression. Univariate and multivariate analyses showed that DEPTOR 
      expression was an independent prognostic factor for DTC recurrence. In 
      conclusion, our data indicate DEPTOR as a novel prognostic marker for DTC.
FAU - Pei, Lei
AU  - Pei L
AD  - Department of General Surgery, Xiangya Hospital, Central South University, 
      Changsha, Hunan 410008, P.R. China.
FAU - Xie, Pingfang
AU  - Xie P
FAU - Zhou, Enxiang
AU  - Zhou E
FAU - Yang, Qian
AU  - Yang Q
FAU - Luo, Yi
AU  - Luo Y
FAU - Tang, Zhonghua
AU  - Tang Z
LA  - eng
PT  - Journal Article
DEP - 20110602
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.1.1 (DEPTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Cell Differentiation
MH  - Cell Line, Tumor
MH  - Disease-Free Survival
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Intracellular Signaling Peptides and Proteins
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - RNA, Messenger/genetics/metabolism
MH  - TOR Serine-Threonine Kinases/genetics/*metabolism
MH  - Thyroid Gland/metabolism/pathology
MH  - Thyroid Neoplasms/*diagnosis/genetics/*pathology
MH  - Young Adult
EDAT- 2011/06/07 06:00
MHDA- 2011/11/02 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/05/02 00:00 [received]
PHST- 2011/05/30 00:00 [accepted]
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/11/02 06:00 [medline]
AID - 10.3892/mmr.2011.503 [doi]
PST - ppublish
SO  - Mol Med Rep. 2011 Sep-Oct;4(5):817-23. doi: 10.3892/mmr.2011.503. Epub 2011 Jun 
      2.