PMID- 21644224
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20110606
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 28
IP  - 3
DP  - 2011 Jun
TI  - [Cytogenetic study of mantle cell lymphoma].
PG  - 283-6
LID - 10.3760/cma.j.issn.1003-9406.2011.03.010 [doi]
AB  - OBJECTIVE: To explore the cytogenetic features of mantle cell lymphoma (MCL). 
      METHODS: Bone marrow cells from 18 MCL patients with bone marrow invasion were 
      cultured for 24 hours, then routine karyotype analysis was performed with 
      R-banding technique. Interphase fluorescence in situ hybridization (FISH) and a 
      panel of 5 probes, including CCND1/IgH, CEP12, D13S319, p53 gene and ATM gene, 
      were used to investigate the cytogenetic features of the samples. RESULTS: 
      Chromosome aberrations were found in 9 (64.3%, 9/14) patients by conventional 
      cytogenetics (CC), 8(57.1%, 8/14) patients had the aberration of t(11; 14), 
      6(42.9%, 6/14) had complex aberrant karyotypes, of which 2 (14.3%, 2/14) had 
      highly complex aberrant karyotypes. A total of 28 abnormalities were detected, 
      among them 19 (67.9%) were structural abnormalities, the other 9 (32.1%) were 
      numerical aberrations. The aberration of t(11; 14) was found in all 18 (100%) 
      patients with MCL by FISH. Secondary cytogenetic aberrations were detected in 14 
      patients by FISH. The most common abnormality was del(11q22.3) (57.1%), the rate 
      of aberrations for del(17p13), + 12 and del(13q14) were 42.9%, 35.7% and 21.4%, 
      respectively. Two (14.3%) and 4 (28.6%) patients were detected to have 
      combinations of 2 and 3 aberrations. CONCLUSION: In addition to t(11; 14), most 
      MCL patients have other chromosome aberrations, especially complex aberrant 
      karyotype.
FAU - Wang, Dong-mei
AU  - Wang DM
AD  - Department of Hematology, the First Affiliated Hospital, Nanjing Medical 
      University, Jiangsu Province Hospital, Nanjing, Jiangsu, 210029 P. R. China.
FAU - Fan, Lei
AU  - Fan L
FAU - Fang, Cheng
AU  - Fang C
FAU - Zhu, Dan-xia
AU  - Zhu DX
FAU - Dong, Huajie
AU  - Dong H
FAU - Yang, Hui
AU  - Yang H
FAU - Qiu, Hai-rong
AU  - Qiu HR
FAU - Hong, Ming
AU  - Hong M
FAU - Qiao, Chun
AU  - Qiao C
FAU - Xu, Wei
AU  - Xu W
FAU - Li, Jian-yong
AU  - Li JY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Female
MH  - Humans
MH  - Karyotyping
MH  - Lymphoma, Mantle-Cell/*genetics/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
EDAT- 2011/06/07 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 940628058 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2011.03.010 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011 Jun;28(3):283-6. doi: 
      10.3760/cma.j.issn.1003-9406.2011.03.010.