PMID- 21644237
OWN - NLM
STAT- MEDLINE
DCOM- 20110930
LR  - 20211203
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 28
IP  - 3
DP  - 2011 Jun
TI  - [Distribution of HLA-C genes and HLA C-B, A-C-B haplotypes in Jinuo, Maonan and 
      Wa ethnic populations in southwest China].
PG  - 341-6
LID - 10.3760/cma.j.issn.1003-9406.2011.03.023 [doi]
AB  - OBJECTIVE: To investigate the distribution of human leukocyte antigen(HLA) class 
      I genes and haplotypes in Jinuo, Maonan and Wa ethnic populations in southwest 
      China. METHODS: Polymerase chain reaction-sequence specific oligonucleotide 
      (PCR-SSO) typing by Luminex was performed to genotype the HLA-C alleles in 
      unrelated healthy individuals in the three populations. HLA C-B, A-C-B haplotypes 
      were computed by combining the previous HLA-A and -B genotyping data using 
      Pypop7.0 software. RESULTS: Eighteen HLA-C genes were identified in the three 
      populations, with 17, 13 and 15 HLA-C genes in Jinuo, Maonan and Wa populations 
      respectively. The alleles with frequency of more than 10% from high to low were 
      C*08:01, C*01:02, C*03:04 and C*07:02 in the Jinuo, C*03:04, C*01:02, C*07:02 and 
      C*08:01 in the Maonan, and C*12:03, C*08:01, C*07:02 and C*04:01 in the Wa. The 
      predominant HLA A-C-B haplotypes were A*02:07-C*01:02-B*46:01, 
      A*11:01-C*08:01-B*15:02 and A*11:01-C*03:04-B*13:01 in the Jinuo, 
      A*11:01-C*03:04-B*13:01, A*02:07-C*01:02-B*46:01, A*11:01-C*08:01-B*15:02 and 
      A*02:03-C*07:02-B*38:02 in the Maonan, and A*11:01-C*08:01-B*15:02, 
      A*11:01-C*12:03-B*15:32 and A*11:01-C*04:01-B*35:01 in the Wa, respectively. 
      CONCLUSION: There were different characteristics in the distributions of HLA-C 
      genes and HLA C-B, A-C-B haplotypes in the Jinuo, Maonan and Wa populations. 
      However, haplotypes C*08:01-B*15:02 and A*11:01-C*08:01-B*15:02 with high 
      frequencies were common in the three populations, which might be the common 
      ancient haplotypes of southern Chinese population. The study of HLA genes and 
      haplotypes in these populations may be of significance in the study of population 
      genetics, transplantation and disease association.
FAU - Shi, Lei
AU  - Shi L
AD  - Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of 
      Medical Sciences & Peking Union Medical College, Kunming, Yunnan, 650118 P. R. 
      China.
FAU - Tao, Yu-fen
AU  - Tao YF
FAU - Shi, Li
AU  - Shi L
FAU - Yao, Yu-feng
AU  - Yao YF
FAU - Yu, Liang
AU  - Yu L
FAU - Lin, Ke-qin
AU  - Lin KQ
FAU - Huang, Xiao-qin
AU  - Huang XQ
FAU - Yi, Wen
AU  - Yi W
FAU - Sun, Hao
AU  - Sun H
FAU - Chu, Jia-you
AU  - Chu JY
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Alleles
MH  - China/ethnology
MH  - Ethnicity/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetics, Population
MH  - *Genotype
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Phylogeny
EDAT- 2011/06/07 06:00
MHDA- 2011/10/01 06:00
CRDT- 2011/06/07 06:00
PHST- 2011/06/07 06:00 [entrez]
PHST- 2011/06/07 06:00 [pubmed]
PHST- 2011/10/01 06:00 [medline]
AID - 940628071 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2011.03.023 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2011 Jun;28(3):341-6. doi: 
      10.3760/cma.j.issn.1003-9406.2011.03.023.