PMID- 21644936
OWN - NLM
STAT- MEDLINE
DCOM- 20111110
LR  - 20110818
IS  - 1600-0412 (Electronic)
IS  - 0001-6349 (Linking)
VI  - 90
IP  - 9
DP  - 2011 Sep
TI  - Expression of matrix metalloproteinases and their inhibitors at the feto-maternal 
      interface in unruptured ectopic tubal pregnancy.
PG  - 966-71
LID - 10.1111/j.1600-0412.2011.01206.x [doi]
AB  - OBJECTIVE: To investigate expression of matrix metalloproteinases (MMPs) and the 
      tissue inhibitors of MMPs (TIMPs) at the feto-maternal interface and 
      non-implantation sites in unruptured tubal pregnancies. DESIGN: Prospective 
      study. Setting. University teaching hospital. POPULATION: Eighteen patients with 
      unruptured tubal pregnancy undergoing salpingectomy. METHODS: 
      Immunohistochemistry was used to detect MMP-2, -9 and -14, and TIMP-1, -2 and -3 
      at the feto-maternal interface and non-implantation regions of the Fallopian 
      tube. Serum levels of human chorionic gonadotropin (beta-hCG) were determined, and 
      trophoblastic invasion was histologiclly classified as stage I when limited to 
      the tubal mucosa and stage II when extending to the muscular layer. MAIN OUTCOME 
      MEASURES: The relation between serum beta-hCG concentration with the depth of 
      trophoblastic invasion into the tubal wall and differential expression of MMPs 
      and TIMPs. RESULTS: A significant difference in the beta-hCG concentrations was seen 
      between stage I and II invasion. Immunoreactivity for MMP-2, -9 and -14, and 
      TIMP-1, -2 and -3 was primarily localized to cytotrophoblasts. At the 
      implantation sites, the intensity of MMPs increased along the invasive pathway 
      towards the maternal interstitium. The expression of MMP-2, MMP-14 and TIMP-3 was 
      localized to the epithelium and smooth muscle cells of the Fallopian tube, while 
      expression of MMP-9, TIMP-1 and TIMP-2 was weak or absent. CONCLUSIONS: Human 
      chorionic gonadotropin correlated positively with invasion stage of trophoblasts. 
      At ectopic implantation sites, the expression of MMPs gradually increased with 
      increasing invasion depth of trophoblasts. TIMP-1 and TIMP-2 were only weakly 
      expressed. The imbalance between expression of MMPs and TIMPs at the ectopic 
      implantation sites may lead to the extensive destructive degradation of the 
      extracellular matrix.
CI  - (c) 2011 The Authors Acta Obstetricia et Gynecologica Scandinavica(c) 2011 Nordic 
      Federation of Societies of Obstetrics and Gynecology.
FAU - Qiu, Xiaoyan
AU  - Qiu X
AD  - Department of Obstetrics and Gynecology, Shanghai First People's Hospital, 
      Shanghai Jiaotong University, Shanghai, PR China.
FAU - Xie, Yi
AU  - Xie Y
FAU - Chen, Lingling
AU  - Chen L
FAU - Gemzell-Danielsson, Kristina
AU  - Gemzell-Danielsson K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110718
PL  - United States
TA  - Acta Obstet Gynecol Scand
JT  - Acta obstetricia et gynecologica Scandinavica
JID - 0370343
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Fallopian Tubes/*metabolism/surgery
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Matrix Metalloproteinases/*metabolism
MH  - Pregnancy
MH  - Pregnancy, Tubal/*metabolism/surgery
MH  - Salpingectomy
MH  - Tissue Inhibitor of Metalloproteinases/*metabolism
MH  - Trophoblasts/*metabolism
EDAT- 2011/06/08 06:00
MHDA- 2011/11/11 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/11/11 06:00 [medline]
AID - 10.1111/j.1600-0412.2011.01206.x [doi]
PST - ppublish
SO  - Acta Obstet Gynecol Scand. 2011 Sep;90(9):966-71. doi: 
      10.1111/j.1600-0412.2011.01206.x. Epub 2011 Jul 18.