PMID- 21645037
OWN - NLM
STAT- MEDLINE
DCOM- 20111115
LR  - 20110727
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 38
IP  - 9
DP  - 2011 Sep
TI  - Polypoid Spitz nevus: two cases evaluated with genetic technique, prolonged 
      follow up, and sentinel lymph node biopsy.
PG  - 747-52
LID - 10.1111/j.1600-0560.2011.01729.x [doi]
AB  - Polypoid Spitz nevus represents a spitzoid melanocytic neoplasm that frequently 
      has worrying and challenging histopathological details. Distinction from polypoid 
      melanoma may not be straightforward. Two cases of polypoid Spitz nevus with 
      striking histopathological features were studied. One case had prolonged follow 
      up (Case 1) and one patient had undergone sentinel lymph node biopsy (Case 2), 
      and fluorescence in situ hybridization (FISH) analysis was also completed (both 
      cases). Follow up and genetic analysis of three control cases of polypoid 
      melanoma is also presented. Our clinical and genetic results suggest that both 
      the polypoid Spitz nevi were benign. The patients are alive with no evidence of 
      disease. FISH analysis did not show abnormalities with probes tested. This is in 
      sharp contrast with the control cases of polypoid melanoma, wherein genomic 
      alterations were detectable. Our data indicate that the two polypoid lesions 
      presented here are most probably benign, despite their worrying histopathological 
      features. More cases with long-term follow up and greater numbers of DNA probes 
      are necessary to extend this conclusion to other ambiguous melanocytic tumors.
CI  - 2011 John Wiley & Sons A/S.
FAU - Pennacchia, Ilaria
AU  - Pennacchia I
AD  - Department of Pathology, Catholic University of Sacred Heart, Rome, Italy 
      Department of Pathology, Forlanini Hospital, Rome, Italy.
FAU - Gasbarra, Rita
AU  - Gasbarra R
FAU - Manente, Liborio
AU  - Manente L
FAU - Pisa, Roberto
AU  - Pisa R
FAU - Garcovich, Simone
AU  - Garcovich S
FAU - Ricci, Roberto
AU  - Ricci R
FAU - Ruggeri, Corrado
AU  - Ruggeri C
FAU - Massi, Guido
AU  - Massi G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20110607
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (DNA, Neoplasm)
RN  - 0 (Oligonucleotide Probes)
SB  - IM
MH  - Adult
MH  - DNA, Neoplasm/genetics/*metabolism
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Male
MH  - Melanocytes/metabolism/pathology
MH  - Melanoma/genetics/metabolism/pathology
MH  - Middle Aged
MH  - Nevus, Epithelioid and Spindle Cell/genetics/*metabolism/*pathology
MH  - Oligonucleotide Probes/chemistry/genetics
MH  - Sentinel Lymph Node Biopsy
MH  - Skin Neoplasms/genetics/*metabolism/*pathology
EDAT- 2011/06/08 06:00
MHDA- 2011/11/16 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/11/16 06:00 [medline]
AID - 10.1111/j.1600-0560.2011.01729.x [doi]
PST - ppublish
SO  - J Cutan Pathol. 2011 Sep;38(9):747-52. doi: 10.1111/j.1600-0560.2011.01729.x. 
      Epub 2011 Jun 7.