PMID- 21645118
OWN - NLM
STAT- MEDLINE
DCOM- 20120105
LR  - 20110916
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 22
IP  - 6
DP  - 2011 Sep
TI  - Educational case series: Mechanisms of drug allergy.
PG  - 559-67
LID - 10.1111/j.1399-3038.2011.01183.x [doi]
AB  - Once administered, a drug can activate the immune system by various mechanisms 
      and lead to a large range of clinical manifestations closely related to the type 
      of immune reaction elicited. Administration of the drug can classically result in 
      an immunoglobulin E (IgE)-type sensitization, but can also result in more complex 
      activation of the immune system potentially resulting in severe syndromes, such 
      as the drug-induced hypersensitivity syndrome (DIHS). Although there has been a 
      major increase in our knowledge over the last years, the exact mechanisms of drug 
      allergy are not well understood for most clinical manifestations. A complex 
      interaction between individual characteristics, environmental factors, and the 
      drug itself is usually responsible for adverse reactions to drugs. In this 
      educational review series, we described three cases of drug allergy: first, a 
      child with a typical IgE-mediated drug allergy, second, a child with a 
      non-immediate reaction to penicillin, and in the third patient, we will discuss 
      the drug-induced hypersensitivity syndrome, which is rare but potentially fatal. 
      These cases are correlated to the immune mechanism potentially involved.
CI  - (c) 2011 John Wiley & Sons A/S.
FAU - Caubet, Jean-Christoph
AU  - Caubet JC
AD  - Department of Child and Adolescent, University Hospitals of Geneva and Medical 
      School of the University of Geneva, Geneva, Switzerland.
FAU - Pichler, Werner J
AU  - Pichler WJ
FAU - Eigenmann, Philippe A
AU  - Eigenmann PA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20110606
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Drug Hypersensitivity/*immunology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
EDAT- 2011/06/08 06:00
MHDA- 2012/01/06 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2012/01/06 06:00 [medline]
AID - 10.1111/j.1399-3038.2011.01183.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2011 Sep;22(6):559-67. doi: 
      10.1111/j.1399-3038.2011.01183.x. Epub 2011 Jun 6.