PMID- 2164532
OWN - NLM
STAT- MEDLINE
DCOM- 19900823
LR  - 20190501
IS  - 0021-9746 (Print)
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 43
IP  - 5
DP  - 1990 May
TI  - Chromosome 11 allele loss in sporadic insulinoma.
PG  - 377-8
AB  - DNA was extracted from tissue samples of three unrelated cases of insulinoma. 
      Chromosome 11 allele loss was investigated using several chromosome 11 specific 
      probes which detect restriction fragment length polymorphisms. In one case, which 
      proved informative for many of the chromosome 11 markers, allele loss was shown 
      on both 11p and 11q. This finding is of considerable interest as the allele loss 
      closely corresponds to that recently reported in insulinomas occurring in the 
      familial multiple endocrine neoplasia type 1 (MEN-1) syndrome.
FAU - Patel, P
AU  - Patel P
AD  - Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford.
FAU - O'Rahilly, S
AU  - O'Rahilly S
FAU - Buckle, V
AU  - Buckle V
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Turner, R C
AU  - Turner RC
FAU - Wainscoat, J S
AU  - Wainscoat JS
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
SB  - IM
MH  - Adenoma, Islet Cell/*genetics
MH  - *Alleles
MH  - Blotting, Southern
MH  - Chromosome Aberrations/*genetics
MH  - Chromosome Disorders
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - Humans
MH  - Insulinoma/*genetics
MH  - Pancreatic Neoplasms/*genetics
PMC - PMC502433
EDAT- 1990/05/01 00:00
MHDA- 1990/05/01 00:01
PMCR- 1993/05/01
CRDT- 1990/05/01 00:00
PHST- 1990/05/01 00:00 [pubmed]
PHST- 1990/05/01 00:01 [medline]
PHST- 1990/05/01 00:00 [entrez]
PHST- 1993/05/01 00:00 [pmc-release]
AID - 10.1136/jcp.43.5.377 [doi]
PST - ppublish
SO  - J Clin Pathol. 1990 May;43(5):377-8. doi: 10.1136/jcp.43.5.377.