PMID- 21645415
OWN - NLM
STAT- MEDLINE
DCOM- 20110912
LR  - 20220408
IS  - 1744-8069 (Electronic)
IS  - 1744-8069 (Linking)
VI  - 7
DP  - 2011 Jun 7
TI  - The analgesic effect of electroacupuncture on acute thermal pain perception--a 
      central neural correlate study with fMRI.
PG  - 45
LID - 10.1186/1744-8069-7-45 [doi]
AB  - BACKGROUND: Electrical acupuncture (EA) has been utilized in acute pain 
      management. However, the neuronal mechanisms that lead to the analgesic effect 
      are still not well defined. The current study assessed the intensity [optimal EA 
      (OI-EA) vs. minimal EA (MI-EA)] effect of non-noxious EA on supraspinal regions 
      related to noxious heat pain (HP) stimulation utilizing an EA treatment protocol 
      for acute pain and functional magnetic resonance imaging (fMRI) with correlation 
      in behavioral changes. Subjects underwent five fMRI scanning paradigms: one with 
      heat pain (HP), two with OI-EA and MI-EA, and two with OI-EA and HP, and MI-EA 
      and HP. RESULTS: While HP resulted in activations (excitatory effect) in 
      supraspinal areas known for pain processing and perception, EA paradigms 
      primarily resulted in deactivations (suppressive effect) in most of these 
      corresponding areas. In addition, OI-EA resulted in a more robust supraspinal 
      sedative effect in comparison to MI-EA. As a result, OI-EA is more effective than 
      MI-EA in suppressing the excitatory effect of HP in supraspinal areas related to 
      both pain processing and perception. CONCLUSION: Intensities of EA plays an 
      important role in modulating central pain perception.
FAU - Shukla, Shivshil
AU  - Shukla S
AD  - Anesthesia Service, Veteran Administrations San Diego Healthcare System, 3350 La 
      Jolla Village Drive, MC 125, San Diego, CA 92161, USA.
FAU - Torossian, Artour
AU  - Torossian A
FAU - Duann, Jeng-Ren
AU  - Duann JR
FAU - Leung, Albert
AU  - Leung A
LA  - eng
GR  - 1K08-1695-01/PHS HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110607
PL  - United States
TA  - Mol Pain
JT  - Molecular pain
JID - 101242662
SB  - IM
MH  - Acupuncture Analgesia/*methods
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain/physiopathology
MH  - *Brain Mapping
MH  - Electroacupuncture/*methods
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Pain Perception/*physiology
MH  - Pain Threshold/physiology
MH  - Temperature
MH  - Young Adult
PMC - PMC3130679
EDAT- 2011/06/08 06:00
MHDA- 2011/09/13 06:00
PMCR- 2011/06/07
CRDT- 2011/06/08 06:00
PHST- 2010/12/08 00:00 [received]
PHST- 2011/06/07 00:00 [accepted]
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/09/13 06:00 [medline]
PHST- 2011/06/07 00:00 [pmc-release]
AID - 1744-8069-7-45 [pii]
AID - 10.1186/1744-8069-7-45 [doi]
PST - epublish
SO  - Mol Pain. 2011 Jun 7;7:45. doi: 10.1186/1744-8069-7-45.