PMID- 21645591
OWN - NLM
STAT- MEDLINE
DCOM- 20120118
LR  - 20211020
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 192
DP  - 2011 Sep 29
TI  - Positive emotional learning is regulated in the medial prefrontal cortex by 
      GluN2B-containing NMDA receptors.
PG  - 515-23
LID - 10.1016/j.neuroscience.2011.05.001 [doi]
AB  - In rats, hedonic ultrasonic vocalizations (USVs) is a validated model of positive 
      affect and is best elicited by rough-and-tumble play. Here we report that 
      modulation of GluN2B-containing NMDA receptors (NMDAR) in the medial prefrontal 
      cortex (MPFC) is involved in positive emotional learning. Rough and tumble play 
      increased both GluN1 and GluN2B NMDAR subunit mRNA and protein levels in the 
      frontal cortex. GLYX-13, a GluN2B-preferring, NMDAR glycine-site partial agonist 
      (1 mg/kg, i.v.) significantly increased positive emotional learning whereas the 
      GluN2B receptor-specific antagonist, ifenprodil (10 mg/kg, i.p.), inhibited 
      positive emotional learning. Animals selectively bred for low rates of hedonic 
      USVs were returned to wild-type levels of positive emotional learning following 
      GLYX-13 treatment. MPFC microinjections of GLYX-13 (0.1-10 mug/side) significantly 
      increased rates of positive emotional learning. Thus GluN2B-containing NMDARs may 
      be involved in positive emotional learning in the MPFC by similar mechanisms as 
      spatial/temporal learning in the hippocampus.
CI  - Copyright (c) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Burgdorf, J
AU  - Burgdorf J
AD  - Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, 
      Northwestern University, Evanston, IL 60201, USA.
FAU - Kroes, R A
AU  - Kroes RA
FAU - Weiss, C
AU  - Weiss C
FAU - Oh, M M
AU  - Oh MM
FAU - Disterhoft, J F
AU  - Disterhoft JF
FAU - Brudzynski, S M
AU  - Brudzynski SM
FAU - Panksepp, J
AU  - Panksepp J
FAU - Moskal, J R
AU  - Moskal JR
LA  - eng
GR  - R01 NS059879/NS/NINDS NIH HHS/United States
GR  - R01 AG017139/AG/NIA NIH HHS/United States
GR  - R01 MH047340/MH/NIMH NIH HHS/United States
GR  - R01NS059879/NS/NINDS NIH HHS/United States
GR  - R37 AG008796/AG/NIA NIH HHS/United States
GR  - R01MH047340/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110607
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Oligopeptides)
RN  - 0 (Protein Subunits)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 6A1X56B95E (GLYX-13 peptide)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Emotions/*physiology
MH  - Learning/*physiology
MH  - Male
MH  - Oligonucleotide Array Sequence Analysis
MH  - Oligopeptides/pharmacology
MH  - Prefrontal Cortex/*metabolism
MH  - Protein Subunits/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Real-Time Polymerase Chain Reaction
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
PMC - PMC3166413
MID - NIHMS294384
EDAT- 2011/06/08 06:00
MHDA- 2012/01/19 06:00
PMCR- 2011/09/29
CRDT- 2011/06/08 06:00
PHST- 2011/03/11 00:00 [received]
PHST- 2011/04/11 00:00 [revised]
PHST- 2011/05/01 00:00 [accepted]
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2012/01/19 06:00 [medline]
PHST- 2011/09/29 00:00 [pmc-release]
AID - S0306-4522(11)00523-9 [pii]
AID - 10.1016/j.neuroscience.2011.05.001 [doi]
PST - ppublish
SO  - Neuroscience. 2011 Sep 29;192:515-23. doi: 10.1016/j.neuroscience.2011.05.001. 
      Epub 2011 Jun 7.