PMID- 21646788
OWN - NLM
STAT- MEDLINE
DCOM- 20110713
LR  - 20110607
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 155 Suppl 1
DP  - 2011
TI  - Qualitative evaluation of adjuvant activities and its application to Th2/17 
      diseases.
PG  - 2-5
LID - 10.1159/000327254 [doi]
AB  - Dendritic cells (DCs) are antigen-presenting cells specialized to activate naive 
      T lymphocytes and initiate primary immune responses. The different classes of 
      specific immune responses are driven by the biased development of 
      antigen-specific helper T cell subsets - that is, Th1, Th2, and Th17 cells - that 
      activate different components of cellular and humoral immunity. DCs reside in an 
      immature state in many nonlymphoid tissues such as the skin or airway mucosa 
      which are highly exposed to allergens, pathogens, and chemicals. T cell receptor 
      stimulation with costimulation allows naive Th cells to develop into effector 
      cells, normally accompanied by high-level expression of selective sets of 
      cytokines. The balance of these cytokines and the resulting class of immune 
      responses depend on the conditions under which DCs are primed. Immunomodulators 
      such as lipopolysaccharides/forskolin/curdlan change the nature of DCs to induce 
      Th1/Th2/Th17 cells thereby designated Th1/Th2/Th17 adjuvants. We have recently 
      found that such activities can be scrutinized by using mixed lymphocyte reaction, 
      cAMP, and differential expression of Notch ligand isoforms. Application of these 
      methods for the analyses of atopic dermatitis and experimental autoimmune 
      encephalomyelitis will be discussed.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Matsushita, Sho
AU  - Matsushita S
AD  - Department of Allergy and Immunology, Faculty of Medicine, Saitama Medical 
      University, Saitama, Japan. shomat@saitama-med.ac.jp
FAU - Takagi, Rie
AU  - Takagi R
FAU - Hashimoto, Kumiko
AU  - Hashimoto K
FAU - Higashi, Takehiro
AU  - Higashi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20110601
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Adjuvants, Immunologic)
SB  - IM
MH  - Adjuvants, Immunologic/analysis/*pharmacology
MH  - Animals
MH  - Dermatitis, Atopic/etiology/immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology/prevention & control
MH  - Humans
MH  - Immune System Diseases/etiology/*immunology/physiopathology/prevention & control
MH  - Th17 Cells/*immunology
MH  - Th2 Cells/*immunology
EDAT- 2011/06/10 06:00
MHDA- 2011/07/14 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/07/14 06:00 [medline]
AID - 000327254 [pii]
AID - 10.1159/000327254 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2011;155 Suppl 1:2-5. doi: 10.1159/000327254. Epub 2011 
      Jun 1.