PMID- 21646827
OWN - NLM
STAT- MEDLINE
DCOM- 20111215
LR  - 20191210
IS  - 1016-5169 (Print)
IS  - 1016-5169 (Linking)
VI  - 39
IP  - 4
DP  - 2011 Jun
TI  - [The relation of serum monocyte chemoattractant protein-1 level with coronary 
      atherosclerotic burden and collateral degree in stable coronary artery disease].
PG  - 269-75
LID - 10.5543/tkda.2011.01290 [doi]
AB  - OBJECTIVES: We investigated whether serum monocyte chemoattractant protein-1 
      (MCP-1) level predicted coronary atherosclerotic burden in patients with stable 
      coronary artery disease and its relationship with coronary collateral grade. 
      STUDY DESIGN: We prospectively included 196 patients (103 males, 93 females; mean 
      age 59 +/- 11 years) who underwent coronary angiography for stable angina pectoris. 
      Serum MCP-1 levels were determined before coronary angiography. Coronary 
      atherosclerotic burden was measured by the Gensini score, and coronary collateral 
      development was assessed by the Rentrop classification. The patients were divided 
      into four groups: those with normal coronary arteries (NCA); those with coronary 
      lesions of <70% luminal obstruction; and those with coronary lesions of >/= 70% 
      luminal obstruction accompanied by a good or poor collateral grade. RESULTS: The 
      mean serum MCP-1 level was higher in patients with coronary lesions compared to 
      patients with NCA (129 +/- 130 vs. 102 +/- 55 pg/ml, p=0.048). Although there were no 
      significant differences in the MCP-1 levels of patients with NCA, with <70% 
      luminal obstruction, and those with a significant luminal obstruction and a poor 
      collateral grade, patients with significant luminal obstruction and a good 
      collateral grade had significantly higher MCP-1 levels compared to the remaining 
      groups (p=0.016). However, in multivariate regression analysis, MCP-1 level was 
      not independently associated with the Gensini score. CONCLUSION: Our findings 
      suggest that serum MCP-1 level is higher in patients with coronary 
      atherosclerosis, without a significant and independent association with coronary 
      atherosclerotic burden. Significantly increased serum MCP-1 levels in patients 
      with a good collateral grade may be an interesting issue of investigation.
FAU - Sahinarslan, Asife
AU  - Sahinarslan A
AD  - Department of Cardiology, Medicine Faculty of Gazi University, Ankara, Turkey. 
      asifesah@yahoo.com
FAU - Kocaman, Sinan Altan
AU  - Kocaman SA
FAU - Topal, Salih
AU  - Topal S
FAU - Ercin, Ugur
AU  - Ercin U
FAU - Bukan, Neslihan
AU  - Bukan N
FAU - Timurkaynak, Timur
AU  - Timurkaynak T
LA  - tur
PT  - Evaluation Study
PT  - Journal Article
TT  - Serum monosit kemoatraktan protein-1 duzeyinin kararli koroner arter hastaliginda 
      koroner aterosklerotik yuk ve kolateral derecesi ile iliskisi.
PL  - Turkey
TA  - Turk Kardiyol Dern Ars
JT  - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
JID - 9426239
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Biomarkers
MH  - Chemokine CCL2/*blood
MH  - Collateral Circulation
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*blood/diagnostic imaging/pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
EDAT- 2011/06/08 06:00
MHDA- 2011/12/16 06:00
CRDT- 2011/06/08 06:00
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/12/16 06:00 [medline]
AID - 10.5543/tkda.2011.01290 [doi]
PST - ppublish
SO  - Turk Kardiyol Dern Ars. 2011 Jun;39(4):269-75. doi: 10.5543/tkda.2011.01290.