PMID- 21647307
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1369-1643 (Electronic)
IS  - 1357-714X (Print)
IS  - 1357-714X (Linking)
VI  - 2011
DP  - 2011
TI  - Connexin 43 is a potential prognostic biomarker for ewing sarcoma/primitive 
      neuroectodermal tumor.
PG  - 971050
LID - 10.1155/2011/971050 [doi]
LID - 971050
AB  - Connexins (Cxs) are building unit proteins of gap junctions (GJs) that are 
      prognostic markers in carcinomas. To investigate the role of Cx in Ewing sarcoma 
      (EWS)/primitive neuroectodermal tumor (PNET), we examined the expression of Cx43 
      and Cx26 in 36 EWS/PNETs and found (1) cytoplasmic Cx43 reactivity in 28/36 (78%) 
      cases. (2) Cx43 score was significantly correlated with overall survival (P = 
      .025). The average scores for patients alive and dead at 3 years are 46.08 and 
      96.98 (P = .004) at 5 years are 46.06 and 96.42 (P = .002). (3) Metastasis had a 
      significant effect on the overall survival (P = .003). (4) Cytoplasmic Cx26 
      reactivity was detected in 2 of 36 (6%) patients who died with metastasis. Our 
      results suggest a possible oncogenic and prognostic role for Cx43 and Cx26 in 
      EWS/PNET. The lack of membranous immunoreactivity suggests that the effect of Cx 
      in EWS/PNET is via a GJ function-independent mechanism.
FAU - Bui, Marilyn M
AU  - Bui MM
AD  - Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, FL 33612, USA.
FAU - Han, Gang
AU  - Han G
FAU - Acs, Geza
AU  - Acs G
FAU - Reed, Damon
AU  - Reed D
FAU - Gonzalez, Ricardo J
AU  - Gonzalez RJ
FAU - Pasha, T L
AU  - Pasha TL
FAU - Zhang, Paul J
AU  - Zhang PJ
LA  - eng
GR  - P30 CA076292/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20110508
PL  - Egypt
TA  - Sarcoma
JT  - Sarcoma
JID - 9709257
PMC - PMC3103998
EDAT- 2011/06/08 06:00
MHDA- 2011/06/08 06:01
PMCR- 2011/05/08
CRDT- 2011/06/08 06:00
PHST- 2010/08/03 00:00 [received]
PHST- 2010/12/03 00:00 [revised]
PHST- 2011/03/09 00:00 [accepted]
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2011/06/08 06:01 [medline]
PHST- 2011/05/08 00:00 [pmc-release]
AID - 10.1155/2011/971050 [doi]
PST - ppublish
SO  - Sarcoma. 2011;2011:971050. doi: 10.1155/2011/971050. Epub 2011 May 8.