PMID- 21647350
OWN - NLM
STAT- MEDLINE
DCOM- 20120224
LR  - 20211020
IS  - 1687-9813 (Electronic)
IS  - 1687-9805 (Print)
IS  - 1687-9805 (Linking)
VI  - 2011
DP  - 2011
TI  - Persistent organic pollutants in serum and several different fat compartments in 
      humans.
PG  - 417980
LID - 10.1155/2011/417980 [doi]
LID - 417980
AB  - BACKGROUND: Chemicals that store in lipid-rich compartments have the potential 
      for long-term disruption of metabolic and endocrine processes. Given the evidence 
      that persistent organic pollutants (POPs) also alter systemic metabolic, 
      endocrine, and immune system functions, it follows that elevated chemical 
      concentrations in intra-abdominal fat may alter function, through local chemical 
      signaling, of visceral organs. Despite this potential, there has been little 
      study defining POP concentrations in live human intra-abdominal fat. It is at 
      present uncertain whether POPs distribute equally to all fat compartments, 
      including fat in serum. METHODS: Seven human subjects scheduled for elective 
      surgery for benign lesions or cancer provided consent for removal of samples of 
      subcutaneous and intra-abdominal fat and/or cancerous tissue. These samples were 
      analyzed for 22 chlorinated pesticides and 10 polychlorinated biphenyl (PCB) 
      congeners by GC/ECD plus GC/MS. RESULTS: In only two subjects were the patterns 
      and relative concentrations of PCBs and pesticides about the same in all fat 
      compartments. In the other subjects, there were major differences in levels in 
      subcutaneous as compared to other compartments, but with some higher and some 
      lower. While the pattern of PCBs in the various compartments matched that of the 
      pesticides in some, it was opposite in others. INTERPRETATION: These results 
      demonstrate a complicated distribution of PCB congeners and pesticides in various 
      lipid compartments. The difference may reflect various K(ow)s, different rates of 
      metabolism, and/or different lengths of exposure. But the results suggest that 
      contaminant levels in serum or even subcutaneous fat do not necessarily indicate 
      concentrations and patterns in other kinds of adipose tissue.
FAU - Yu, George W
AU  - Yu GW
AD  - George Washington University Medical Center, Washington, DC 20037, USA. 
      george.yu8@gmail.com
FAU - Laseter, John
AU  - Laseter J
FAU - Mylander, Charles
AU  - Mylander C
LA  - eng
PT  - Journal Article
DEP - 20110410
PL  - United States
TA  - J Environ Public Health
JT  - Journal of environmental and public health
JID - 101516361
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Chromatography, Gas
MH  - Electrons
MH  - Environmental Pollutants/*analysis/blood
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*analysis/blood
MH  - Intra-Abdominal Fat/*chemistry
MH  - Male
MH  - Neoplasms/chemistry
MH  - Pesticides/*analysis/blood
MH  - Polychlorinated Biphenyls/*analysis/blood
MH  - Subcutaneous Fat, Abdominal/*chemistry
MH  - United States
PMC - PMC3103883
EDAT- 2011/06/08 06:00
MHDA- 2012/03/01 06:00
PMCR- 2011/04/10
CRDT- 2011/06/08 06:00
PHST- 2011/01/19 00:00 [received]
PHST- 2011/02/10 00:00 [accepted]
PHST- 2011/06/08 06:00 [entrez]
PHST- 2011/06/08 06:00 [pubmed]
PHST- 2012/03/01 06:00 [medline]
PHST- 2011/04/10 00:00 [pmc-release]
AID - 10.1155/2011/417980 [doi]
PST - ppublish
SO  - J Environ Public Health. 2011;2011:417980. doi: 10.1155/2011/417980. Epub 2011 
      Apr 10.