PMID- 21649860
OWN - NLM
STAT- MEDLINE
DCOM- 20111025
LR  - 20110704
IS  - 1744-313X (Electronic)
IS  - 1744-3121 (Linking)
VI  - 38
IP  - 4
DP  - 2011 Aug
TI  - cDNA cloning, genomic structure and mRNA expression pattern of porcine type I 
      interferons receptor 2 gene.
PG  - 339-45
LID - 10.1111/j.1744-313X.2011.01018.x [doi]
AB  - Type I interferons (IFN) are important mediators of the host defence against 
      viruses through binding to the cell surface receptors, among which the binding to 
      type I IFN receptor 2 (IFNAR2) is the very first step initiating a complex signal 
      transduction cascade. By using RT-PCR and 5' RACE approaches, we obtained porcine 
      IFNAR2 cDNA, the nucleotide identity of its coding region is 57.53%, 67.45%, 
      74.07% and 74.63% to those of mouse, human, sheep and cattle, respectively; and 
      the deduced protein of which shares 38.18%, 55.29%, 62.01% and 63.39% identity to 
      those of mouse, human, sheep and cattle, respectively. The genomic structure of 
      porcine IFNAR2 gene consists of nine exons and eight introns. Porcine IFNAR2 mRNA 
      expression was detected in all tissues examined, being strong in the spleen, 
      small intestine, cerebrum and uterus tissues and relatively weak in the stomach 
      tissues. As compared with piglets, the expression of IFNAR2 mRNA was 
      significantly higher in both liver and spleen of Laiwu adult pigs (P < 0.01); in 
      Duroc pigs, however, significantly higher IFNAR2 mRNA expression was only found 
      in adult liver (P < 0.05). In Duroc x Landrace x Yorkshire commercial pigs 
      infected with porcine reproductive and respiratory syndrome virus (PRRSV), the 
      expression of IFNAR2 mRNA in lung tissue was significantly down-regulated as 
      compared to uninfected ones (P < 0.05).
CI  - (c) 2011 Blackwell Publishing Ltd.
FAU - Xing, F
AU  - Xing F
AD  - Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control 
      and Prevention, College of Animal Science and College of Veterinary Medicine, 
      Shandong Agricultural University, Taian, China.
FAU - Li, Y
AU  - Li Y
FAU - Liang, S
AU  - Liang S
FAU - Liu, D
AU  - Liu D
FAU - Jiang, C
AU  - Jiang C
FAU - Zhang, Y
AU  - Zhang Y
FAU - Kang, L
AU  - Kang L
FAU - Jiang, Y
AU  - Jiang Y
LA  - eng
SI  - GENBANK/HQ603084
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110607
PL  - England
TA  - Int J Immunogenet
JT  - International journal of immunogenetics
JID - 101232337
RN  - 0 (DNA, Complementary)
RN  - 0 (RNA, Messenger)
RN  - 156986-95-7 (Receptor, Interferon alpha-beta)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - DNA, Complementary/genetics
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation/immunology
MH  - Genome/*genetics
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Porcine Reproductive and Respiratory Syndrome/genetics/immunology
MH  - Porcine respiratory and reproductive syndrome virus/immunology
MH  - RNA, Messenger/*genetics
MH  - Receptor, Interferon alpha-beta/chemistry/*genetics/immunology
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
MH  - Swine/classification/*genetics
EDAT- 2011/06/09 06:00
MHDA- 2011/10/26 06:00
CRDT- 2011/06/09 06:00
PHST- 2011/06/09 06:00 [entrez]
PHST- 2011/06/09 06:00 [pubmed]
PHST- 2011/10/26 06:00 [medline]
AID - 10.1111/j.1744-313X.2011.01018.x [doi]
PST - ppublish
SO  - Int J Immunogenet. 2011 Aug;38(4):339-45. doi: 10.1111/j.1744-313X.2011.01018.x. 
      Epub 2011 Jun 7.