PMID- 21652249
OWN - NLM
STAT- MEDLINE
DCOM- 20111018
LR  - 20211020
IS  - 1094-6950 (Print)
IS  - 1094-6950 (Linking)
VI  - 14
IP  - 3
DP  - 2011 Jul-Sep
TI  - Lean mass predicts hip geometry in men and women with non-insulin-requiring type 
      2 diabetes mellitus.
PG  - 332-9
LID - 10.1016/j.jocd.2011.04.007 [doi]
AB  - Persons with type 2 diabetes mellitus (T2DM) are at increased risk for hip 
      fracture despite normal bone mineral density (BMD). The contribution of body 
      composition to hip geometry, a measure of hip strength, has not been studied in 
      T2DM. We hypothesized that lean mass would predict hip geometry. Subjects (n=134) 
      for this cross-sectional analysis were men and women aged 56 +/- 6yr with 
      non-insulin-requiring T2DM. Fat and lean mass were measured with dual-energy 
      X-ray absorptiometry (DXA). Abdominal fat was measured with magnetic resonance 
      imaging. Hip geometry parameters including section modulus, cross-sectional area, 
      and buckling ratio were estimated from DXA using validated formulae. Subjects had 
      normal BMD, elevated body mass indices (29-41 kg/m(2)), and controlled T2DM 
      (hemoglobin A1c: 5.1-8.3%). In bivariate analysis, lean mass was positively 
      associated with section modulus and cross-sectional area in both sexes 
      (r=0.36-0.55, p<0.05). In multivariate analyses, lean mass remained a significant 
      predictor of all hip strength estimates in both sexes. In women alone, fat mass 
      predicted parameters of hip strength. These data demonstrate that lean mass is 
      significantly associated with hip strength in subjects with non-insulin-requiring 
      T2DM. Resistance exercises that build lean mass may be an intervention for hip 
      fracture prevention in T2DM, although additional research is needed.
CI  - Copyright (c) 2011 The International Society for Clinical Densitometry. Published 
      by Elsevier Inc. All rights reserved.
FAU - Moseley, Kendall F
AU  - Moseley KF
AD  - Division of Endocrinology & Metabolism, The Johns Hopkins Hospital, Baltimore, 
      MD, USA. kmosele@jhmi.edu
FAU - Dobrosielski, Devon A
AU  - Dobrosielski DA
FAU - Stewart, Kerry J
AU  - Stewart KJ
FAU - Sellmeyer, Deborah E
AU  - Sellmeyer DE
FAU - Jan De Beur, Suzanne M
AU  - Jan De Beur SM
LA  - eng
SI  - ClinicalTrials.gov/NCT00212303
GR  - R01 DK062368-01A2/DK/NIDDK NIH HHS/United States
GR  - T32 AG000120-25/AG/NIA NIH HHS/United States
GR  - 5T32 AG000120/AG/NIA NIH HHS/United States
GR  - R01 DK062368/DK/NIDDK NIH HHS/United States
GR  - T32 AG000120/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110611
PL  - United States
TA  - J Clin Densitom
JT  - Journal of clinical densitometry : the official journal of the International 
      Society for Clinical Densitometry
JID - 9808212
SB  - IM
MH  - *Absorptiometry, Photon
MH  - Adiposity
MH  - Adult
MH  - Aged
MH  - Body Composition
MH  - *Body Mass Index
MH  - *Bone Density
MH  - Diabetes Mellitus, Type 2/*diagnostic imaging
MH  - Female
MH  - Hip Joint/*diagnostic imaging
MH  - Humans
MH  - Male
MH  - Middle Aged
PMC - PMC3150220
MID - NIHMS292159
COIS- No potential conflicts of interest relevant to this article were reported.
EDAT- 2011/06/10 06:00
MHDA- 2011/10/19 06:00
PMCR- 2012/07/01
CRDT- 2011/06/10 06:00
PHST- 2011/02/11 00:00 [received]
PHST- 2011/04/12 00:00 [revised]
PHST- 2011/04/14 00:00 [accepted]
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/10/19 06:00 [medline]
PHST- 2012/07/01 00:00 [pmc-release]
AID - S1094-6950(11)00105-3 [pii]
AID - 10.1016/j.jocd.2011.04.007 [doi]
PST - ppublish
SO  - J Clin Densitom. 2011 Jul-Sep;14(3):332-9. doi: 10.1016/j.jocd.2011.04.007. Epub 
      2011 Jun 11.