PMID- 21654180
OWN - NLM
STAT- MEDLINE
DCOM- 20120604
LR  - 20220309
IS  - 1660-2110 (Electronic)
IS  - 1660-2110 (Linking)
VI  - 119
IP  - 1
DP  - 2011
TI  - Parallel deterioration of albuminuria, arterial stiffness and left ventricular 
      mass in essential hypertension: integrating target organ damage.
PG  - c27-34
LID - 10.1159/000324215 [doi]
AB  - BACKGROUND: Albuminuria, arterial stiffening and left ventricular hypertrophy 
      (LVH) constitute target organ damage. We estimated whether increased urinary 
      albumin excretion, assessed by albumin-to-creatine ratio (ACR), and carotid to 
      femoral pulse wave velocity (c-f PWV) were accompanied by augmented left 
      ventricular (LV) mass index (LVMI) in hypertension. METHODS: In 428 non-diabetic 
      untreated hypertensives (257 men, mean age = 52 years, office blood pressure (BP) 
      = 146/93 mm Hg) the distributions of ACR and c-f PWV were split by the median (8 
      mg/g and 7.8 m/s, respectively). RESULTS: Age, male sex, 24 h systolic BP, ACR 
      and c-f PWV were the independent predictors of LVMI (R(2) = 0.478, p < 0.0001). 
      Among patients with low ACR (n = 198), those with high c-f PWV (n = 84) compared 
      to those with low c-f PWV (n = 114) were characterized by increased LVMI (by 8.9 
      g/m(2), p = 0.012) and prevalence of LVH (30 vs. 14%, p = 0.015). Similarly among 
      patients with high ACR (n = 230), those with high c-f PWV (n = 123) compared to 
      those with low c-f PWV (n = 107) exhibited heightened LVMI (by 13.6 g/m(2), p = 
      0.001). CONCLUSIONS: Increased ACR in conjunction with pronounced arterial 
      stiffness is accompanied by augmented LV mass and higher LVH rates. Furthermore, 
      the interrelationships between albuminuria, c-f PWV and LVMI suggest parallel 
      target organ damage progression.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Andrikou, Eirini
AU  - Andrikou E
AD  - First Cardiology Clinic, University of Athens, Hippokration Hospital, Greece.
FAU - Tsioufis, Costas
AU  - Tsioufis C
FAU - Dimitriadis, Kyriakos
AU  - Dimitriadis K
FAU - Flessas, Dimitrios
AU  - Flessas D
FAU - Chatzistamatiou, Vagelis
AU  - Chatzistamatiou V
FAU - Grassos, Charalampos
AU  - Grassos C
FAU - Papavasiliou, Maria
AU  - Papavasiliou M
FAU - Papadopoulos, Dimitris
AU  - Papadopoulos D
FAU - Stefanadis, Christodoulos
AU  - Stefanadis C
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20110608
PL  - Switzerland
TA  - Nephron Clin Pract
JT  - Nephron. Clinical practice
JID - 101159763
SB  - IM
MH  - Adult
MH  - Albuminuria/epidemiology/pathology/*physiopathology
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Hypertension/epidemiology/pathology/*physiopathology
MH  - Hypertrophy, Left Ventricular/epidemiology/pathology/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Vascular Stiffness/*physiology
EDAT- 2011/06/10 06:00
MHDA- 2012/06/05 06:00
CRDT- 2011/06/10 06:00
PHST- 2010/09/09 00:00 [received]
PHST- 2011/01/07 00:00 [accepted]
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2012/06/05 06:00 [medline]
AID - 000324215 [pii]
AID - 10.1159/000324215 [doi]
PST - ppublish
SO  - Nephron Clin Pract. 2011;119(1):c27-34. doi: 10.1159/000324215. Epub 2011 Jun 8.