PMID- 21654846
OWN - NLM
STAT- MEDLINE
DCOM- 20120214
LR  - 20221207
IS  - 1476-5470 (Electronic)
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 12
IP  - 7
DP  - 2011 Oct
TI  - SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients.
PG  - 523-30
LID - 10.1038/gene.2011.25 [doi]
AB  - Although several major histocompatibility complex (MHC)-wide single-nucleotide 
      polymorphism (SNP) studies have been performed in populations of European 
      descent, none have been performed in Asian populations. The objective of this 
      study was to identify human leukocyte antigen (HLA) loci associated with multiple 
      sclerosis (MS) in a Japanese population genotyped for 3534 MHC region SNPs. Using 
      a logistic regression model, two SNPs (MHC Class III SNP rs422951 in the NOTCH4 
      gene and MHC Class II SNP rs3997849, susceptible alleles A and G, respectively) 
      were independently associated with MS susceptibility (204 patients; 280 
      controls), two (MHC Class II SNP rs660895 and MHC Class I SNP rs2269704 in the 
      NRM gene, susceptible alleles G and G, respectively) with aquaporin-4- (AQP4-) MS 
      susceptibility (149 patients; 280 controls) and a single SNP (MHC Class II SNP 
      rs1694112, susceptible allele G) was significant when contrasting AQP4+ against 
      AQP4- patients. Haplotype analysis revealed a large susceptible association, 
      likely DRB1*04 or a locus included in the DRB1*04 haplotype, with AQP4- MS, which 
      excluded DRB1*15:01. This study is the largest study of the HLA's contribution to 
      MS in Japanese individuals.
FAU - McElroy, J P
AU  - McElroy JP
AD  - Department of Neurology, University of California, San Francisco (UCSF), San 
      Francisco, CA 94143, USA. Joseph.P.McElroy@gmail.com
FAU - Isobe, N
AU  - Isobe N
FAU - Gourraud, P A
AU  - Gourraud PA
FAU - Caillier, S J
AU  - Caillier SJ
FAU - Matsushita, T
AU  - Matsushita T
FAU - Kohriyama, T
AU  - Kohriyama T
FAU - Miyamoto, K
AU  - Miyamoto K
FAU - Nakatsuji, Y
AU  - Nakatsuji Y
FAU - Miki, T
AU  - Miki T
FAU - Hauser, S L
AU  - Hauser SL
FAU - Oksenberg, J R
AU  - Oksenberg JR
FAU - Kira, J
AU  - Kira J
LA  - eng
GR  - RG3060C8/RG/CSR NIH HHS/United States
GR  - R01NS46297/NS/NINDS NIH HHS/United States
GR  - R01 NS026799/NS/NINDS NIH HHS/United States
GR  - R01 NS046297/NS/NINDS NIH HHS/United States
GR  - U19AI067152/AI/NIAID NIH HHS/United States
GR  - U19 AI067152/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20110609
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Female
MH  - Genetic Association Studies
MH  - HLA Antigens/*genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Haplotypes
MH  - Humans
MH  - Japan
MH  - Male
MH  - Multiple Sclerosis/*genetics
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
PMC - PMC3361962
MID - NIHMS374860
COIS- Conflict of interest The authors declare no conflict of interest.
EDAT- 2011/06/10 06:00
MHDA- 2012/02/15 06:00
PMCR- 2012/05/29
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2012/02/15 06:00 [medline]
PHST- 2012/05/29 00:00 [pmc-release]
AID - gene201125 [pii]
AID - 10.1038/gene.2011.25 [doi]
PST - ppublish
SO  - Genes Immun. 2011 Oct;12(7):523-30. doi: 10.1038/gene.2011.25. Epub 2011 Jun 9.