PMID- 21654890
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110714
LR  - 20211020
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Print)
IS  - 1177-5467 (Linking)
VI  - 5
DP  - 2011
TI  - Macular laser photocoagulation guided by spectral-domain optical coherence 
      tomography versus fluorescein angiography for diabetic macular edema.
PG  - 613-7
LID - 10.2147/OPTH.S16833 [doi]
AB  - BACKGROUND: The aim of this study was to compare the efficacy of spectral-domain 
      optical coherence tomography (SD-OCT) and fluorescein angiography (FA) in the 
      guidance of macular laser photocoagulation for diabetic macular edema. METHODS: 
      This was a prospective interventional clinical comparative pilot study. Forty 
      eyes from 24 consecutive patients with diabetic macular edema were allocated to 
      receive laser photocoagulation guided by SD-OCT or FA. Best-corrected visual 
      acuity (BCVA), central macular thickness, and retinal volume were assessed at 
      baseline and two months after treatment. RESULTS: Subjects treated using 
      FA-guided laser improved BCVA from the logarithm of the minimum angle of 
      resolution (logMAR) 0.52 +/- 0.2 to 0.37 +/- 0.2 (P < 0.001), and decreased mean 
      central macular thickness from 397.25 +/- 139.1 to 333.50 +/- 105.7 mum (P < 0.001) 
      and retinal volume from 12.61 +/- 1.6 to 10.94 +/- 1.4 mm(3) (P < 0.001). Subjects 
      treated using SD-OCT guided laser had improved BCVA from 0.48 +/- 0.2 to 0.33 +/- 0.2 
      logMAR (P < 0.001), and decreased mean central macular thickness from 425.90 +/- 
      149.6 to 353.4 +/- 140 mum (P < 0.001) and retinal volume from 12.38 +/- 2.1 to 11.53 
      +/- 1.1 mm(3) (P < 0.001). No significant differences between the groups were found 
      in two-month BCVA (P = 0.505), two-month central macular thickness (P = 0.660), 
      or two-month retinal volume (P = 0.582). CONCLUSION: The short-term results of 
      this pilot study suggest that SD-OCT is a safe and effective technique and could 
      be considered as a valid alternative to FA in the guidance of macular laser 
      photocoagulation treatment for diabetic macular edema.
FAU - Gallego-Pinazo, Roberto
AU  - Gallego-Pinazo R
AD  - Department of Ophthalmology, Hospital Universitario La Fe, Valencia, Spain;
FAU - Suelves-Cogollos, Ana Marina
AU  - Suelves-Cogollos AM
FAU - Dolz-Marco, Rosa
AU  - Dolz-Marco R
FAU - Arevalo, J Fernando
AU  - Arevalo JF
FAU - Garcia-Delpech, Salvador
AU  - Garcia-Delpech S
FAU - Mullor, J Luis
AU  - Mullor JL
FAU - Diaz-Llopis, Manuel
AU  - Diaz-Llopis M
LA  - eng
PT  - Journal Article
DEP - 20110515
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC3102594
OTO - NOTNLM
OT  - diabetic macular edema
OT  - fluorescein angiography
OT  - macular laser photocoagulation
OT  - spectral-domain optical coherence tomography
EDAT- 2011/06/10 06:00
MHDA- 2011/06/10 06:01
PMCR- 2011/05/15
CRDT- 2011/06/10 06:00
PHST- 2011/05/12 00:00 [received]
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/06/10 06:01 [medline]
PHST- 2011/05/15 00:00 [pmc-release]
AID - opth-5-613 [pii]
AID - 10.2147/OPTH.S16833 [doi]
PST - ppublish
SO  - Clin Ophthalmol. 2011;5:613-7. doi: 10.2147/OPTH.S16833. Epub 2011 May 15.