PMID- 21655150
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121010
LR  - 20211020
IS  - 1718-7729 (Electronic)
IS  - 1198-0052 (Print)
IS  - 1198-0052 (Linking)
VI  - 18
IP  - 3
DP  - 2011 Jun
TI  - Cord stem-cell transplantation in Ontario: do we need a public bank?
PG  - e121-5
AB  - It has been 21 years since the first successful use of umbilical cord blood as a 
      source of donor cells for hematopoietic stem cell transplantation (HSCT). Over 
      those years, cord blood transplantation (CBT) has shown marked success as an 
      effective modality in the treatment of children and adults with hematologic 
      malignancies, marrow failure, immunodeficiency, hemoglobinopathy, and inherited 
      metabolic diseases. Furthermore, transplantation without full human leukocyte 
      antigen (HLA) matching is possible and, despite a lower incidence of 
      graft-versus-host disease, graft-versus-leukemia effect is preserved. More than 
      20,000 cbts have been performed worldwide. Ontario is the most populated province 
      in Canada, and its cbt numbers have increased dramatically in recent years, but 
      most of the umbilical cord blood units are purchased from unrelated international 
      registries. There is no public cord bank in Ontario, but there is a private cord 
      banking option, and notably, Ontario has the largest number of live births in 
      Canada [approximately 40% of all Canadian live births per year occur in Ontario 
      (Statistics Canada, 2007)]. In this brief review, the pros and cons of private 
      and public cord banking and the feasibility of starting an Ontario public cord 
      bank are discussed.
FAU - Gassas, A
AU  - Gassas A
AD  - Division of Hematology/Oncology/Blood and Marrow Transplantation, Hospital for 
      Sick Children, University of Toronto, Toronto, ON. adam.gassas@sickkids.ca
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Curr Oncol
JT  - Current oncology (Toronto, Ont.)
JID - 9502503
PMC - PMC3108872
OTO - NOTNLM
OT  - Cord stem-cell transplantation
OT  - Ontario
OT  - children
OT  - private cord banking
OT  - public cord banking
EDAT- 2011/06/10 06:00
MHDA- 2011/06/10 06:01
PMCR- 2011/06/01
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/06/10 06:01 [medline]
PHST- 2011/06/01 00:00 [pmc-release]
AID - conc-18-e121 [pii]
AID - 10.3747/co.v18i3.742 [doi]
PST - ppublish
SO  - Curr Oncol. 2011 Jun;18(3):e121-5. doi: 10.3747/co.v18i3.742.