PMID- 21656201
OWN - NLM
STAT- MEDLINE
DCOM- 20120221
LR  - 20211020
IS  - 1546-9549 (Electronic)
IS  - 1546-9530 (Linking)
VI  - 8
IP  - 4
DP  - 2011 Dec
TI  - Does contractility modulation have a role in the treatment of heart failure?
PG  - 260-5
LID - 10.1007/s11897-011-0067-3 [doi]
AB  - Cardiac resynchronization therapy (CRT) is an established therapy for patients 
      with systolic dysfunction, QRS duration greater than 120 ms, and New York Heart 
      Association (NYHA) class III or IV symptoms. However, most patients with heart 
      failure have QRS duration below 120 ms and 30% or more of CRT recipients are 
      nonresponders. Cardiac contractility modulation (CCM) signals are nonexcitatory 
      electrical impulses applied during the absolute refractory period that are 
      intended to enhance contractile strength independent of QRS duration. Myocardial 
      biopsy studies suggest that modulation of protein phosphorylation and gene 
      expression underlie the mechanisms by which CCM exerts its effects. Two 
      prospective randomized studies have investigated the impact of CCM on exercise 
      tolerance and quality of life in patients with chronic heart failure. These 
      studies have included predominantly patients with NYHA class III heart failure 
      with QRS duration below 130 ms. This review summarizes results of these clinical 
      studies and outlines additional studies underway to further clarify the role of 
      CCM in the treatment of heart failure.
FAU - Burkhoff, Daniel
AU  - Burkhoff D
AD  - Division of Cardiology, Columbia University, 177 Fort Washington Avenue, New 
      York, NY 10032, USA. db59@columbia.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Heart Fail Rep
JT  - Current heart failure reports
JID - 101196487
SB  - IM
MH  - *Cardiac Resynchronization Therapy
MH  - Electrocardiography
MH  - Heart Failure/*physiopathology/therapy
MH  - Humans
MH  - *Myocardial Contraction
EDAT- 2011/06/10 06:00
MHDA- 2012/02/22 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2012/02/22 06:00 [medline]
AID - 10.1007/s11897-011-0067-3 [doi]
PST - ppublish
SO  - Curr Heart Fail Rep. 2011 Dec;8(4):260-5. doi: 10.1007/s11897-011-0067-3.