PMID- 21656215
OWN - NLM
STAT- MEDLINE
DCOM- 20111028
LR  - 20211020
IS  - 1432-1106 (Electronic)
IS  - 0014-4819 (Linking)
VI  - 212
IP  - 3
DP  - 2011 Jul
TI  - Modulation of the soleus H reflex by electrical subcortical stimuli in humans.
PG  - 439-48
LID - 10.1007/s00221-011-2750-8 [doi]
AB  - Over the past two decades, the H reflex has been used as a neural tool to assess 
      the effect on the motoneuronal pool of conditioning volleys in supraspinal 
      descending tracts elicited by transcranial magnetic stimulation (TMS) or auditory 
      stimuli. However, mechanisms mediating such modulation are unclear. These 
      hypothesized neural pathways are likely to be affected by single electrical 
      stimulus applied through the electrodes implanted in the subthalamic nucleus for 
      deep brain stimulation (sSTNDBS). To improve our knowledge on such mechanisms, we 
      examined in 11 Parkinson's disease patients the effects of conditioning sSTNDBS 
      applied contralateral and ipsilateral to the H reflex recording on the amplitude 
      of the soleus H reflex, at interstimulus intervals (ISIs) between 0 and 110 ms. 
      There was a significant main effect of the ISI (P<0.001) and of the sSTNDBS 
      stimulation side (P=0.019) on the percentage change in the soleus H-reflex 
      amplitude. Contralateral sSTNDBS modulation of the soleus H reflex resembles that 
      of TMS in healthy subjects with two facilitation phases (at 5-20 ms and at 60 
      ms), while after ipsilateral sSTNDBS, there is only a single facilitation phase 
      peaking up at 5 ms later than the first facilitation period observed with 
      contralateral stimulation. These findings contribute to the discussion of the 
      mechanisms underlying the excitability of the spinal alpha motoneuron pool and 
      the modulation of the H reflex by supraspinal stimuli.
FAU - Costa, Joao
AU  - Costa J
AD  - EMG and Motor Control Unit, Neurology Department, Hospital Clinic, Universitat de 
      Barcelona, IDIBAPS (Institut d'Investigacio Biomedica August Pi i Sunyer), 
      Villarroel, 170, 08036, Barcelona, Spain.
FAU - Guzman, Jessica
AU  - Guzman J
FAU - Valldeoriola, Francesc
AU  - Valldeoriola F
FAU - Rumia, Jordi
AU  - Rumia J
FAU - Tolosa, Eduardo
AU  - Tolosa E
FAU - Casanova-Molla, Jordi
AU  - Casanova-Molla J
FAU - Valls-Sole, Josep
AU  - Valls-Sole J
LA  - eng
PT  - Journal Article
DEP - 20110609
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
SB  - IM
MH  - Aged
MH  - Deep Brain Stimulation
MH  - Electric Stimulation
MH  - Female
MH  - H-Reflex/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle, Skeletal/*physiology
MH  - Parkinson Disease/*physiopathology/therapy
MH  - Subthalamic Nucleus/*physiopathology
EDAT- 2011/06/10 06:00
MHDA- 2011/10/29 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/03/09 00:00 [received]
PHST- 2011/05/20 00:00 [accepted]
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/10/29 06:00 [medline]
AID - 10.1007/s00221-011-2750-8 [doi]
PST - ppublish
SO  - Exp Brain Res. 2011 Jul;212(3):439-48. doi: 10.1007/s00221-011-2750-8. Epub 2011 
      Jun 9.