PMID- 21656454
OWN - NLM
STAT- MEDLINE
DCOM- 20110815
LR  - 20110609
IS  - 1439-4413 (Electronic)
IS  - 0012-0472 (Linking)
VI  - 136
IP  - 24
DP  - 2011 Jun
TI  - [Diagnostics and treatment in functional pancreatic neuroendocrine tumours].
PG  - 1319-30
LID - 10.1055/s-0031-1280554 [doi]
AB  - Pancreatic neuroendocrine tumours (PNET) are rare entities with an annual 
      incidence of < 100,000. About 1 - 2 % of pancreatic neoplasias are neuroendocrine 
      tumours. About one third of these tumours secrete biologically active substances 
      that lead to development of specific clinical syndromes. PNET may occur 
      sporadically or in association with hereditary syndromes, such as multiple 
      endocrine neoplasia type 1 (MEN1). Among the functional PNET, insulinomas and 
      gastrinomas are the most common entities. In contrast, vasoactive intetinale 
      peptide (VIP)-secreting tumours, glucagonomas, serotonin-secreting carcinoid 
      tumors, and tumours with secretion of ectopic hormones, such as calcitonin, are 
      extremely rare. Once diagnosis has been established on the basis of clinical and 
      laboratory findings, localization of the source of pathologic hormone secretion 
      is warranted. Imaging methods frequently used for localization of PNET comprise 
      anatomical imaging modalities, computed tomography, and magnetic resonance 
      imaging, endoscopic ultrasound, selective arterial catheterization with hepatic 
      venous sampling, DTPA-octreotid scintigraphy and DOTA-D-Phe(1)-Tyr(3)-octreotid 
      positron emission tomography. Therapy is based on the specific tumour entity and 
      the extent of the disease. In the majority of patients, even in the case of 
      malignant disease, a surgical approach is warranted, eventually combined with a 
      medical treatment.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Mussig, K
AU  - Mussig K
AD  - Klinik fur Innere Medizin mit Gastroenterologie und Onkologie, 
      Florence-Nightingale-Krankenhaus, Kaiserswerther Diakonie, Dusseldorf.
FAU - Dudziak, K
AU  - Dudziak K
FAU - Horger, M
AU  - Horger M
FAU - Anlauf, M
AU  - Anlauf M
FAU - Goretzki, P E
AU  - Goretzki PE
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Diagnostik und Therapie bei funktionell aktiven pankreatischen neuroendokrinen 
      Tumoren.
DEP - 20110607
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - Fasting
MH  - Female
MH  - Gastrinoma/diagnosis/pathology/therapy
MH  - Glucagonoma/diagnosis/pathology/therapy
MH  - Humans
MH  - Hypoglycemia/etiology
MH  - Insulinoma/diagnosis/pathology/therapy
MH  - Malignant Carcinoid Syndrome/diagnosis/pathology/therapy
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/pathology/therapy
MH  - Neoplasm Staging
MH  - Neuroectodermal Tumors, Primitive/*diagnosis/pathology/therapy
MH  - Pancreatic Neoplasms/*diagnosis/pathology/therapy
MH  - Prognosis
MH  - Somatostatinoma/diagnosis/pathology/therapy
MH  - Tomography, Spiral Computed
MH  - Vipoma/diagnosis/pathology/therapy
EDAT- 2011/06/10 06:00
MHDA- 2011/08/16 06:00
CRDT- 2011/06/10 06:00
PHST- 2011/06/10 06:00 [entrez]
PHST- 2011/06/10 06:00 [pubmed]
PHST- 2011/08/16 06:00 [medline]
AID - 10.1055/s-0031-1280554 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 2011 Jun;136(24):1319-30. doi: 10.1055/s-0031-1280554. Epub 
      2011 Jun 7.