PMID- 21658421
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 10
DP  - 2011 Oct
TI  - Association of susceptibility to Takayasu arteritis in Chinese Han patients with 
      HLA-DPB1.
PG  - 893-6
LID - 10.1016/j.humimm.2011.05.001 [doi]
AB  - Takayasu arteritis (TA) is a chronic large-vessel vasculitis of unknown etiology. 
      Human leukocyte antigen (HLA) alleles play an important role in the development 
      of TA. The association between HLA-DPB1 and TA in Chinese Han patients remains 
      unclear. We examined the genotypes of 72 Chinese patients with TA and 180 healthy 
      unrelated individuals who did not have any history of chronic disease. HLA-DPB1 
      genotypes were determined using polymerase chain reaction sequence-specific 
      primer (PCR-SSP). The frequencies of DPB1*09 and DPB1*1701 among the TA patients 
      were significant higher than among the controls. The mean age of the onset of TA 
      in patients with DPB1*1701 alleles was significant earlier than the DPB1*1701 
      negative patients. Our results indicated that the HLA-DPB1*09 and DPB1*1701 
      alleles might increase the susceptibility to TA, and the individuals possessing 
      DPB1*1701 had the earlier onset age of the disease. Further studies on the 
      mechanism underlying are warranted.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Lv, Naqiang
AU  - Lv N
AD  - Department of Cardiology, FuWai Hospital and Cardiovascular Institute, Chinese 
      Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
FAU - Dang, Aimin
AU  - Dang A
FAU - Wang, Zhiguang
AU  - Wang Z
FAU - Zheng, Deyu
AU  - Zheng D
FAU - Liu, Guozhang
AU  - Liu G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110524
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Alleles
MH  - *Asian People
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - *HLA-DP beta-Chains/genetics/immunology
MH  - Humans
MH  - Incidence
MH  - Leukocytes/chemistry/cytology/*immunology
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Polymerase Chain Reaction
MH  - *Takayasu Arteritis/ethnology/genetics/immunology/physiopathology
EDAT- 2011/06/11 06:00
MHDA- 2012/01/12 06:00
CRDT- 2011/06/11 06:00
PHST- 2011/03/06 00:00 [received]
PHST- 2011/05/02 00:00 [revised]
PHST- 2011/05/13 00:00 [accepted]
PHST- 2011/06/11 06:00 [entrez]
PHST- 2011/06/11 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
AID - S0198-8859(11)00108-X [pii]
AID - 10.1016/j.humimm.2011.05.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Oct;72(10):893-6. doi: 10.1016/j.humimm.2011.05.001. Epub 2011 
      May 24.