PMID- 21658778
OWN - NLM
STAT- MEDLINE
DCOM- 20111221
LR  - 20181201
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 134
IP  - 1-3
DP  - 2011 Nov
TI  - Genetic association between bipolar disorder and 524A>C (Leu133Ile) polymorphism 
      of CNR2 gene, encoding for CB2 cannabinoid receptor.
PG  - 427-30
LID - 10.1016/j.jad.2011.05.023 [doi]
AB  - INTRODUCTION: Several studies provided evidence that the endocannabinoid system 
      (ECS) is involved in psychiatric diseases, like major depression, schizophrenia 
      and bipolar disorder (BD), mainly focusing on CB1 cannabinoid receptor, and FAAH, 
      the fatty acid amide hydrolase involved in endocannabinoid metabolism. In this 
      study we investigated the possible association of BD with three missense SNPs, of 
      the gene CNR2, encoding for CB2 cannabinoid receptor. METHODS: The possible 
      association between BD and three CNR2 missense SNPs, namely rs2501432 (315A>G; 
      Arg63Gln), rs41311993 (524C>A; Leu133Ile) and rs2229579 (1073C>T; Tyr316His), was 
      investigated through a case-control study. Eighty patients and one hundred and 
      sixty healthy subjects were recruited. Allele Specific Oligonucleotide (ASO)-PCR 
      and restriction fragment length polymorphism (RFLP) methods were used for 
      genotyping. RESULTS: A statistically significant association was found between BD 
      and the CNR2 524C>A; Leu133Ile (P(chi(2)) = 0.001; OR = 4.74; 95% C.I. = 
      2.52-10.50) while no statistically significant difference between BD and control 
      group was observed for the other two SNPs. CONCLUSION: Though further 
      investigations are necessary to confirm this data, our results suggest that CB2 
      cannabinoid receptor may play a role in BD.
CI  - Copyright (c) 2011 Elsevier B.V. All rights reserved.
FAU - Minocci, D
AU  - Minocci D
AD  - Dept of Psychiatry, Unit of Neurobiology, Pharmacology and Biotechnology, 
      University of Pisa, Pisa, Italy.
FAU - Massei, J
AU  - Massei J
FAU - Martino, A
AU  - Martino A
FAU - Milianti, M
AU  - Milianti M
FAU - Piz, L
AU  - Piz L
FAU - Di Bello, D
AU  - Di Bello D
FAU - Sbrana, A
AU  - Sbrana A
FAU - Martinotti, E
AU  - Martinotti E
FAU - Rossi, A M
AU  - Rossi AM
FAU - Nieri, P
AU  - Nieri P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20110611
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Cannabinoid Receptor Modulators)
RN  - 0 (Receptor, Cannabinoid, CB1)
RN  - 0 (Receptor, Cannabinoid, CB2)
RN  - EC 3.5.- (Amidohydrolases)
RN  - EC 3.5.1.- (fatty-acid amide hydrolase)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Amidohydrolases/genetics/metabolism
MH  - Bipolar Disorder/*genetics
MH  - Cannabinoid Receptor Modulators/genetics
MH  - Case-Control Studies
MH  - Depressive Disorder, Major/genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Mutation, Missense
MH  - Polymorphism, Genetic
MH  - Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide
MH  - Receptor, Cannabinoid, CB1/genetics/metabolism
MH  - Receptor, Cannabinoid, CB2/*genetics/metabolism
MH  - Schizophrenia/genetics
EDAT- 2011/06/11 06:00
MHDA- 2011/12/22 06:00
CRDT- 2011/06/11 06:00
PHST- 2011/03/13 00:00 [received]
PHST- 2011/05/14 00:00 [revised]
PHST- 2011/05/15 00:00 [accepted]
PHST- 2011/06/11 06:00 [entrez]
PHST- 2011/06/11 06:00 [pubmed]
PHST- 2011/12/22 06:00 [medline]
AID - S0165-0327(11)00269-2 [pii]
AID - 10.1016/j.jad.2011.05.023 [doi]
PST - ppublish
SO  - J Affect Disord. 2011 Nov;134(1-3):427-30. doi: 10.1016/j.jad.2011.05.023. Epub 
      2011 Jun 11.