PMID- 21659742
OWN - NLM
STAT- MEDLINE
DCOM- 20120127
LR  - 20111011
IS  - 1421-9735 (Electronic)
IS  - 0253-5068 (Linking)
VI  - 32
IP  - 3
DP  - 2011
TI  - A heparin-coated dialysis filter (AN69 ST) does not reduce clotting during 
      hemodialysis when compared to a conventional polysulfone filter (Fx8).
PG  - 151-5
LID - 10.1159/000325227 [doi]
AB  - BACKGROUND: We investigated whether the heparin-coated AN69 ST hemodialysis (HD) 
      filter induced less hypercoagulability during HD than a conventional polysulfone 
      filter (Fx8). METHODS: In a crossover design, 11 patients were treated 
      alternately with AN69 ST and Fx8 filters (45 sessions). All filters were primed 
      with unfractionated heparin (UFH) and unadsorbed UFH was removed by saline 
      flushing. Half the conventional dalteparin dose was given as a bolus dose at the 
      start of HD. Clotting was evaluated hourly in the venous air trap. Prothrombin 
      fragments 1 and 2 (PF1 + 2), antithrombin (AT), beta-TG and anti-FXa activity were 
      repeatedly measured. RESULTS: One patient treated with enalapril had two repeated 
      adverse reactions to the AN69 ST filter and was excluded from the study. Use of 
      the AN69 ST filter did not decrease the mean clot score or PF1 + 2, but decreased 
      beta-TG compared to the Fx8 filter. CONCLUSION: The heparin-coated AN69 ST filter 
      did not induce less coagulation when compared to the Fx8 filter.
CI  - Copyright (c) 2011 S. Karger AG, Basel.
FAU - Sagedal, Solbjorg
AU  - Sagedal S
AD  - Department of Nephrology, Oslo University Hospital Ulleval, Oslo, Norway.
FAU - Witczak, Bartlomiej J
AU  - Witczak BJ
FAU - Osnes, Kare
AU  - Osnes K
FAU - Hartmann, Anders
AU  - Hartmann A
FAU - Os, Ingrid
AU  - Os I
FAU - Eikvar, Lars
AU  - Eikvar L
FAU - Klingenberg, Olav
AU  - Klingenberg O
FAU - Brosstad, Frank
AU  - Brosstad F
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20110610
PL  - Switzerland
TA  - Blood Purif
JT  - Blood purification
JID - 8402040
RN  - 0 (Anticoagulants)
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Membranes, Artificial)
RN  - 0 (Polymers)
RN  - 0 (Sulfones)
RN  - 25135-51-7 (polysulfone P 1700)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anticoagulants/*pharmacology
MH  - Blood Coagulation/*drug effects
MH  - *Coated Materials, Biocompatible
MH  - Cross-Over Studies
MH  - Female
MH  - Heparin/*pharmacology
MH  - Humans
MH  - Male
MH  - *Membranes, Artificial
MH  - Middle Aged
MH  - *Polymers
MH  - Renal Dialysis/*instrumentation/methods
MH  - *Sulfones
EDAT- 2011/06/11 06:00
MHDA- 2012/01/28 06:00
CRDT- 2011/06/11 06:00
PHST- 2010/08/27 00:00 [received]
PHST- 2011/02/08 00:00 [accepted]
PHST- 2011/06/11 06:00 [entrez]
PHST- 2011/06/11 06:00 [pubmed]
PHST- 2012/01/28 06:00 [medline]
AID - 000325227 [pii]
AID - 10.1159/000325227 [doi]
PST - ppublish
SO  - Blood Purif. 2011;32(3):151-5. doi: 10.1159/000325227. Epub 2011 Jun 10.