PMID- 21663781
OWN - NLM
STAT- MEDLINE
DCOM- 20120111
LR  - 20221207
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 72
IP  - 10
DP  - 2011 Oct
TI  - Human leukocyte antigen class I haplotypes of human immunodeficiency 
      virus-1-infected persons on Likoma Island, Malawi.
PG  - 877-80
LID - 10.1016/j.humimm.2011.05.003 [doi]
AB  - Human leukocyte antigen (HLA) allele frequencies vary between different human 
      populations, with implications both for the evolutionary pressures shaping those 
      populations as well as for the outcome of new infectious epidemics. We defined 
      HLA class I types in a well-described cohort of persons on Likoma Island in 
      Malawi, a population for which there are lacking data on allelic frequencies. The 
      profile of HLA frequencies was similar but phylogenetically distinct from those 
      of other sub-Saharan African populations in neighboring regions. The most common 
      A alleles included A30, A23, A28 (A*68), and A2, and the most common B alleles 
      included B15 (group), B53, B58, and B44. Notably, the frequency of B53, which is 
      protective against malaria, was similar to that of other malaria-endemic African 
      countries, and higher than that in countries with less malaria. This is the first 
      reported significant dataset of HLA class I allelic frequencies in Malawians.
CI  - Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Yang, Otto O
AU  - Yang OO
AD  - Department of Microbiology, Immunology, and Molecular Genetics, University of 
      California, Los Angeles, California, USA. oyang@mednet.ucla.edu
FAU - Lewis, Martha J
AU  - Lewis MJ
FAU - Reed, Elaine F
AU  - Reed EF
FAU - Gjertson, David W
AU  - Gjertson DW
FAU - Kalilani-Phiri, Linda
AU  - Kalilani-Phiri L
FAU - Mkandawire, James
AU  - Mkandawire J
FAU - Helleringer, Stephane
AU  - Helleringer S
FAU - Kohler, Hans-Peter
AU  - Kohler HP
LA  - eng
GR  - HD044228/HD/NICHD NIH HHS/United States
GR  - P20 AG012836/AG/NIA NIH HHS/United States
GR  - HD053781/HD/NICHD NIH HHS/United States
GR  - R24 HD044964-05/HD/NICHD NIH HHS/United States
GR  - P30 AG012836/AG/NIA NIH HHS/United States
GR  - R01 HD053781-05/HD/NICHD NIH HHS/United States
GR  - R01 HD041713-05/HD/NICHD NIH HHS/United States
GR  - P2C HD044964/HD/NICHD NIH HHS/United States
GR  - R56 AI042819/AI/NIAID NIH HHS/United States
GR  - HD/MH41713/HD/NICHD NIH HHS/United States
GR  - R01 HD044228-04/HD/NICHD NIH HHS/United States
GR  - R01 HD053781/HD/NICHD NIH HHS/United States
GR  - P30 AG012836-13/AG/NIA NIH HHS/United States
GR  - R01 HD044228/HD/NICHD NIH HHS/United States
GR  - AI042819/AI/NIAID NIH HHS/United States
GR  - R01 AI042819-09/AI/NIAID NIH HHS/United States
GR  - AG012836/AG/NIA NIH HHS/United States
GR  - R24 HD044964/HD/NICHD NIH HHS/United States
GR  - HD044964/HD/NICHD NIH HHS/United States
GR  - R01 AI042819/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110524
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Black People/*genetics
MH  - Cohort Studies
MH  - Female
MH  - *Founder Effect
MH  - Gene Frequency
MH  - Genotype
MH  - Geography
MH  - HIV Infections/*immunology/virology
MH  - HIV-1/*physiology
MH  - HLA-A Antigens/*analysis/genetics/immunology
MH  - HLA-B Antigens/*analysis/genetics/immunology
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Leukocytes/*chemistry/cytology/immunology
MH  - Malawi
MH  - Male
MH  - Phylogeny
MH  - Phylogeography
PMC - PMC3175254
MID - NIHMS298666
EDAT- 2011/06/15 06:00
MHDA- 2012/01/12 06:00
PMCR- 2012/10/01
CRDT- 2011/06/14 06:00
PHST- 2011/03/07 00:00 [received]
PHST- 2011/05/03 00:00 [revised]
PHST- 2011/05/13 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/01/12 06:00 [medline]
PHST- 2012/10/01 00:00 [pmc-release]
AID - S0198-8859(11)00110-8 [pii]
AID - 10.1016/j.humimm.2011.05.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2011 Oct;72(10):877-80. doi: 10.1016/j.humimm.2011.05.003. Epub 2011 
      May 24.