PMID- 21664434
OWN - NLM
STAT- MEDLINE
DCOM- 20120705
LR  - 20220330
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 190
DP  - 2011 Sep 8
TI  - Activation of peripheral delta-opioid receptors leads to anti-hyperalgesic 
      responses in the masseter muscle of male and female rats.
PG  - 379-85
LID - 10.1016/j.neuroscience.2011.05.062 [doi]
AB  - In this project, we examined peripheral delta-opioid receptor (DOR)-mediated 
      anti-hyperalgesic responses in the context of an acute orofacial muscle pain 
      condition in both male and female rats. We also investigated whether the 
      ATP-sensitive K+ channel (KATP), a downstream target of OR signaling, contributes 
      to DOR-mediated anti-hyperalgesic responses. Local pretreatment of the masseter 
      with a DOR agonist, [D-Pen(2), D-Pen(6)]-enkephalin (DPDPE), dose-dependently 
      attenuated capsaicin-induced mechanical hypersensitivity in both male and female 
      rats. However, there were sex differences in the potency of local DPDPE in that a 
      10-fold higher dose of DPDPE was required in female rats to produce the level of 
      anti-hyperalgesia achieved in male rats. The sex differences in the DPDPE effect 
      may not be fully explained by DOR expression level since there was no significant 
      sex difference in DOR mRNA levels in trigeminal ganglia (TG). Finally, 
      pretreatment of the masseter with the KATP antagonist, glibenclamide, 
      significantly blocked the effects of DPDPE in male rats suggesting that the 
      peripheral DOR effect is mediated by the KATP. These studies revealed novel 
      information about sex differences with regards to peripherally localized 
      DOR-mediated anti-hyperalgesia under an orofacial muscle pain condition.
CI  - Copyright (c) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
FAU - Saloman, J L
AU  - Saloman JL
AD  - Program in Neuroscience, Department of Neural and Pain Sciences, University of 
      Maryland Baltimore School of Dentistry, 650 W. Baltimore Street, Baltimore, MD 
      21201, USA.
FAU - Niu, K Y
AU  - Niu KY
FAU - Ro, J Y
AU  - Ro JY
LA  - eng
GR  - R01 DE019448/DE/NIDCR NIH HHS/United States
GR  - R01 DE019448-03/DE/NIDCR NIH HHS/United States
GR  - R01 DE19448/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20110606
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Receptors, Opioid, delta)
RN  - 88373-73-3 (Enkephalin, D-Penicillamine (2,5)-)
SB  - IM
MH  - Analgesics, Opioid/pharmacology/*therapeutic use
MH  - Animals
MH  - Enkephalin, D-Penicillamine (2,5)-/pharmacology/*therapeutic use
MH  - Facial Pain/*drug therapy/metabolism
MH  - Female
MH  - Hyperalgesia/*drug therapy/metabolism
MH  - Male
MH  - Masseter Muscle/drug effects/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Opioid, delta/*metabolism
MH  - Sex Characteristics
PMC - PMC3156332
MID - NIHMS311297
COIS- There are no conflicts of interest associated with the present study.
EDAT- 2011/06/15 06:00
MHDA- 2012/07/06 06:00
PMCR- 2012/09/08
CRDT- 2011/06/14 06:00
PHST- 2011/04/05 00:00 [received]
PHST- 2011/05/23 00:00 [revised]
PHST- 2011/05/25 00:00 [accepted]
PHST- 2011/06/14 06:00 [entrez]
PHST- 2011/06/15 06:00 [pubmed]
PHST- 2012/07/06 06:00 [medline]
PHST- 2012/09/08 00:00 [pmc-release]
AID - S0306-4522(11)00652-X [pii]
AID - 10.1016/j.neuroscience.2011.05.062 [doi]
PST - ppublish
SO  - Neuroscience. 2011 Sep 8;190:379-85. doi: 10.1016/j.neuroscience.2011.05.062. 
      Epub 2011 Jun 6.